Wang Chong, Wang Jiali, Zhang Zhuohao, Wang Qiao, Shang Luoran
Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology) Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Research (Wash D C). 2023;6:0083. doi: 10.34133/research.0083. Epub 2023 Mar 15.
Drug therapy is among the most widely used methods in disease treatment. However, there remains a trade-off problem between drug dosage and toxicity. Blood purification by adsorption of excessive drugs during clinical treatment could be a solution for enhancing therapeutic efficacy while maintaining normal body function. Here, inspired by the intrinsic action mechanism of chemotherapeutic agents in targeting DNA in the cell nucleus, we present DNA-polyelectrolyte composite responsive microparticles for chemotherapeutics cleaning. The presence of DNA in the microparticles enabled the adsorption of multiple common chemotherapy drugs. Moreover, the microparticles are endowed with a porous structure and a photothermal-responsive ability, both of which contribute to improved adsorption by enhancing the contact of the microparticles with the drug solution. On the basis of that, the microparticles are integrated into a herringbone-structured microfluidic chip. The fluid mixing capacity and the enhanced drug cleaning efficiency of the microfluidic platform are validated on-chip. These results indicate the value of the DNA-polyelectrolyte composite responsive microparticles for drug capture and blood purification. We believe the microparticle-integrated microfluidic platform could provide a solution for settling the dosage-toxicity trade-off problems in chemotherapy.
药物治疗是疾病治疗中应用最广泛的方法之一。然而，药物剂量与毒性之间仍然存在权衡问题。在临床治疗过程中，通过吸附过量药物进行血液净化可能是一种在维持身体正常功能的同时提高治疗效果的解决方案。在此，受化疗药物在细胞核中靶向DNA的内在作用机制启发，我们提出了用于化疗药物清除的DNA-聚电解质复合响应性微粒。微粒中DNA的存在使得能够吸附多种常见化疗药物。此外，微粒具有多孔结构和光热响应能力，这两者都通过增强微粒与药物溶液的接触来促进吸附。在此基础上，将微粒集成到一种人字形结构的微流控芯片中。在芯片上验证了微流控平台的流体混合能力和提高的药物清除效率。这些结果表明了DNA-聚电解质复合响应性微粒在药物捕获和血液净化方面的价值。我们相信，集成微粒的微流控平台可以为解决化疗中的剂量-毒性权衡问题提供一种解决方案。
