Te Whatu Ora (Health New Zealand) Waitaha Canterbury, Christchurch, 8011, New Zealand.
University of Otago, Christchurch, 8140, New Zealand.
Chin J Integr Med. 2023 Jul;29(7):590-599. doi: 10.1007/s11655-023-3632-1. Epub 2023 Mar 21.
This study examined whether a 4-week group-based mindfulness intervention would be superior in reducing psychological distress in colorectal cancer (CRC) patients compared to a psychoeducation and cognitive behavioural skills learning support active control group.
Patients with CRC were randomized via Computerised Permuted Block Randomisation to mindfulness or active control groups (2-h weekly sessions over 4 weeks). Outcomes were measured pre-intervention, and 8 weeks and 6 months post-baseline. The primary outcome was psychological distress measured by the Hospital Anxiety and Depression Scale. Secondary outcomes were generic quality of life (QoL), disease specific QoL, mindfulness, and intervention credibility and acceptability.
Sixty-eight participants were randomized to mindfulness (n=35) or active control group (n=33). Uptake of potentially eligible patients consenting was low (28.0%) and the dropout rate was 33.8%. Depression scores were reduced in both groups at week 8 (P=0.020). Control participants had greater improvement in generic mental QoL scores at week 8 than mindfulness (P=0.023). In disease specific QoL, there was reduction in impotence symptom in the mindfulness group (P=0.022) and reduction in faecal incontinence in the control group (P=0.019). The embarrassment symptom had a significantly lower increase in the mindfulness group at week 8 compared to the control group (P=0.009). Both groups rated the treatments as credible and acceptable.
Mindfulness was not superior to the active control group in terms of alleviating psychological distress but both treatments were associated with some improvements in depression. There was low uptake of both interventions. (Trial registration number: ACTRN12616001033437).
本研究旨在探讨为期 4 周的基于小组的正念干预是否优于心理教育和认知行为技能学习支持的积极对照组，从而减轻结直肠癌（CRC）患者的心理困扰。
通过计算机化的随机分组将 CRC 患者随机分配至正念组或积极对照组（每周 2 小时，共 4 周）。在干预前、8 周和 6 个月时进行了结果测量。主要结局是使用医院焦虑和抑郁量表（HADS）测量心理困扰。次要结局是一般健康相关生活质量（HRQoL）、疾病特异性 HRQoL、正念和干预可信度和可接受性。
68 名患者被随机分配至正念组（n=35）或积极对照组（n=33）。有资格的潜在患者同意率低（28.0%），脱落率为 33.8%。两组在第 8 周时抑郁评分均降低（P=0.020）。对照组在第 8 周时的一般心理 HRQoL 评分改善幅度大于正念组（P=0.023）。在疾病特异性 HRQoL 方面，正念组的勃起功能障碍症状有所减轻（P=0.022），对照组的粪便失禁症状有所减轻（P=0.019）。与对照组相比，正念组在第 8 周时尴尬症状的增加幅度明显较低（P=0.009）。两组均认为治疗方法可信且可接受。
正念组在缓解心理困扰方面并不优于积极对照组，但两种治疗方法均与抑郁的某些改善相关。两种干预措施的参与率均较低。（试验注册号：ACTRN12616001033437）。
