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Efficient non-viral delivery of macromolecules in human primary hematopoietic stem cells and lymphocytes.

作者信息

Zhang Chuan-Ping, Qiu Hou-Yuan, Zhang Cai-Xiang, Zhang Yu-Ming, Zhang Yi-Zhou, Yin Hao, Zhang Ke-Qin, Zhang Ying

机构信息

State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, Kunming 650091, China.

Department of Rheumatology and Immunology, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.

出版信息

J Mol Cell Biol. 2023 Aug 3;15(3). doi: 10.1093/jmcb/mjad018.

DOI:10.1093/jmcb/mjad018
PMID:36945107
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10481097/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/413c/10481097/10a704651fc2/mjad018fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/413c/10481097/10a704651fc2/mjad018fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/413c/10481097/10a704651fc2/mjad018fig1.jpg

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J Control Release. 2022 Feb;342:345-361. doi: 10.1016/j.jconrel.2022.01.013. Epub 2022 Jan 10.
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Editing a γ-globin repressor binding site restores fetal hemoglobin synthesis and corrects the sickle cell disease phenotype.
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Rapid generation of long, chemically modified pegRNAs for prime editing.用于碱基编辑的长链化学修饰pegRNA的快速生成。
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