Department of Cardiology, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Turkey.
Department of Cardiology, Cardiovascular Hospital, Ankara City Hospital, Ankara, Turkey.
Turk J Med Sci. 2022 Dec;52(6):1829-1838. doi: 10.55730/1300-0144.5529. Epub 2022 Dec 21.
The level of nitric oxide (NO) is important to protect the heart from ischemic damage in acute coronary syndrome (ACS) patients. S-nitrosothiol (SNO) is a molecule that represents the main form of NO storage in the vascular structure. In addition, dynamic thiol/disulfide homeostasis (TDH) is known to play an important role in maintaining the oxidant-antioxidant balance. In this study, our aim is to evaluate the oxidative/nitrosative stress status according to SNO level and TDH in patients with ACS.
The study included 124 patients who were admitted to the emergency service and 124 consecutive individuals who applied to the cardiology outpatient clinic with cardiac complaints and underwent coronary angiography (CAG). Blood was drawn from all participants included in the study to determine SNO, nitrite, total thiol, native thiol, and disulfide levels after 12 h of fasting.
Serum SNO levels were found to be significantly lower in ACS patients compared to the control group (0.3 ± 0.08 vs. 0.4 ± 0.10 μmol/L, successively, p < 0.001). In addition, while the total thiol, native thiol, and native thiol/total thiol levels were lower in the patient group compared to the control group, nitrite, disulfide/native thiol and disulfide/total thiol levels were higher. As a result of multivariate logistic regression analysis, it was determined that age, gender, smoking, low-density lipoprotein cholesterol, glycosylated haemoglobin, and SNO levels were independent predictors in predicting ACS patients.
S-nitrosothiol and thiol levels were found to be significantly lower in ACS patients. In addition, SNO molecule was independently associated with the presence of ACS diagnosis.
一氧化氮（NO）水平对于保护急性冠状动脉综合征（ACS）患者的心脏免受缺血性损伤很重要。S-亚硝基硫醇（SNO）是血管结构中NO 的主要储存形式的一种分子。此外，动态硫醇/二硫键平衡（TDH）已知在维持氧化还原平衡中发挥重要作用。在这项研究中，我们的目的是根据 ACS 患者的 SNO 水平和 TDH 评估氧化/硝化应激状态。
该研究纳入了 124 名因急性胸痛入住急诊的患者和 124 名因胸痛就诊心内科并行冠状动脉造影（CAG）的连续个体。所有纳入研究的参与者均禁食 12 小时后采血，以测定 SNO、硝酸盐、总巯基、天然巯基和二硫键水平。
与对照组相比，ACS 患者的血清 SNO 水平显著降低（0.3±0.08 与 0.4±0.10 μmol/L，p＜0.001）。此外，与对照组相比，患者组的总巯基、天然巯基和天然巯基/总巯基水平较低，而硝酸盐、二硫键/天然巯基和二硫键/总巯基水平较高。多元逻辑回归分析结果表明，年龄、性别、吸烟、低密度脂蛋白胆固醇、糖化血红蛋白和 SNO 水平是预测 ACS 患者的独立预测因素。
ACS 患者的 S-亚硝基硫醇和巯基水平显著降低。此外，SNO 分子与 ACS 诊断的存在独立相关。
