中国西南地区成年恒河猴近视的患病率及特征。
Prevalence and Characteristics of Myopia in Adult Rhesus Macaques in Southwest China.
机构信息
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
出版信息
Transl Vis Sci Technol. 2023 Mar 1;12(3):21. doi: 10.1167/tvst.12.3.21.
PURPOSE
To investigate the prevalence of myopia in a large cohort of adult rhesus macaques at Yunnan Province in southwest China and describe the characteristics of myopic rhesus macaque eyes.
METHODS
A total of 219 rhesus macaques 14.07 ± 2.72 years old (range, 8-21) were randomly recruited for this study. We performed fundus photography and measurements of cycloplegic refractive error (RE) and axial length (AL) on macaques.
RESULTS
A total of 429 eyes of 219 macaques were examined. The median RE was -1.25 diopters (D), and the median AL was 18.69 mm. The prevalence of myopia was 62.47%, and one-third of the myopic eyes were highly myopic. The presence of fundus tessellations was higher in myopic eyes than non-myopic eyes (42.54% vs. 6.21%). The cutoff value for the presence of tessellations was -3.52 D for RE and 19.38 mm for AL. In myopic eyes, there were significant differences between grade 1 and grade 3 fundus tessellations on RE (-5.57 ± 2.97 D vs. -8.13 ± 3.51 D) and AL (19.66 ± 0.55 mm vs. 20.60 ± 1.06 mm). Beta-peripapillary atrophy (β-PPA) was found in 48.10% of myopic eyes and 6.83% of non-myopic eyes. The presence of β-PPA is associated with the presence of fundus tessellations, AL, and RE. The presence of β-PPA was higher in grade 3 than grade 1 fundus tessellations (94.4% vs. 76%).
CONCLUSIONS
More than half of adult rhesus macaques in southwest China are myopic, and one-third of the myopic ones are highly myopic. Similar to humans, tessellated fundi and β-PPA are the characteristic signs of myopic rhesus macaques. Adult rhesus macaques are optimal animal models for research on the pathogenesis of myopia.
TRANSLATIONAL RELEVANCE
This study not only provides a reference for the refractive state and AL in myopic rhesus macaques but also indicates that adult rhesus macaques with spontaneous myopia are optimal animal models for research on the pathogenesis of myopia.
目的
调查中国西南部云南省一个大型恒河猴成年人群的近视患病率，并描述近视恒河猴眼睛的特征。
方法
共随机招募了 219 只年龄为 14.07±2.72 岁（8-21 岁）的恒河猴进行本研究。我们对恒河猴进行眼底照相和睫状肌麻痹屈光不正（RE）和眼轴（AL）测量。
结果
共检查了 219 只恒河猴的 429 只眼。中位 RE 为-1.25 屈光度（D），中位 AL 为 18.69mm。近视患病率为 62.47%，三分之一的近视眼为高度近视。在近视眼中，眼底格子状变性的存在高于非近视眼（42.54%比 6.21%）。RE 的格子状变性存在的截断值为-3.52D，AL 的截断值为 19.38mm。在近视眼中，1 级和 3 级眼底格子状变性在 RE（-5.57±2.97D 比-8.13±3.51D）和 AL（19.66±0.55mm 比 20.60±1.06mm）上有显著差异。β-视盘旁萎缩（β-PPA）在 48.10%的近视眼中和 6.83%的非近视眼中发现。β-PPA 的存在与眼底格子状变性、AL 和 RE 有关。3 级格子状变性的β-PPA 发生率高于 1 级（94.4%比 76%）。
结论
中国西南部的成年恒河猴有一半以上是近视，三分之一的近视是高度近视。与人类相似，格子状眼底和β-PPA 是近视恒河猴的特征性标志。成年恒河猴是研究近视发病机制的理想动物模型。
翻译后内容与原文内容不符，正确的翻译为：
目的
调查中国西南部云南省一个大型恒河猴成年人群的近视患病率，并描述近视恒河猴眼睛的特征。
方法
共随机招募了 219 只年龄为 14.07±2.72 岁（8-21 岁）的恒河猴进行本研究。我们对恒河猴进行眼底照相和睫状肌麻痹屈光不正（RE）和眼轴（AL）测量。
结果
共检查了 219 只恒河猴的 429 只眼。中位 RE 为-1.25 屈光度（D），中位 AL 为 18.69mm。近视患病率为 62.47%，三分之一的近视眼为高度近视。在近视眼中，眼底格子状变性的存在高于非近视眼（42.54%比 6.21%）。RE 的格子状变性存在的截断值为-3.52D，AL 的截断值为 19.38mm。在近视眼中，1 级和 3 级眼底格子状变性在 RE（-5.57±2.97D 比-8.13±3.51D）和 AL（19.66±0.55mm 比 20.60±1.06mm）上有显著差异。β-视盘旁萎缩（β-PPA）在 48.10%的近视眼中和 6.83%的非近视眼中发现。β-PPA 的存在与眼底格子状变性、AL 和 RE 有关。3 级格子状变性的β-PPA 发生率高于 1 级（94.4%比 76%）。
结论
中国西南部的成年恒河猴有一半以上是近视，三分之一的近视是高度近视。与人类相似，格子状眼底和β-PPA 是近视恒河猴的特征性标志。成年恒河猴是研究近视发病机制的理想动物模型。
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