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重回病毒的未来:呼吸道合胞病毒、人冠状病毒 OC43 和鼻病毒三重感染的病例报告。

Back to the future of viruses: a case of triple coinfection caused by respiratory syncytial virus, human coronavirus OC43, and rhinovirus.

机构信息

Maladies infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, 92380 Garches, France; INSERM UMR1173, Université Versailles-Saint-Quentin Paris Saclay, 78180 Versailles, France.

Maladies infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, 92380 Garches, France.

出版信息

Int J Infect Dis. 2023 May;130:205-207. doi: 10.1016/j.ijid.2023.03.024. Epub 2023 Mar 21.

DOI:10.1016/j.ijid.2023.03.024
PMID:36948447
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10028211/
Abstract

We present the case of an 81-year-old man, who was immunocompetent, who was admitted to the hospital with symptoms of fever and dyspnea suspected to be caused by COVID-19. Further examination revealed a triple coinfection, as determined by multiplex polymerase chain reaction testing, caused by the respiratory syncytial virus, human coronavirus OC43, and rhinovirus. Upon auscultation, diffuse wheezing without crackles was detected. After ruling out the possibility of acute heart failure with pulmonary edema, the patient was treated with nebulization of terbutaline for a period of 72 hours. This case serves to demonstrate the potential dangers of lifting barrier measures, such as mandatory face masks in high-risk areas, during the fall-winter season. In addition, it highlights the challenges that may arise in the post-COVID-19 era because reliance on flu vaccinations alone may not be sufficient.

摘要

我们报告了一例 81 岁免疫功能正常的男性患者,因疑似 COVID-19 引起的发热和呼吸困难而住院。进一步的检查通过多重聚合酶链反应检测确定为三重感染,由呼吸道合胞病毒、人类冠状病毒 OC43 和鼻病毒引起。听诊时,检测到弥漫性哮鸣音但无爆裂音。排除急性心力衰竭伴肺水肿的可能性后,患者接受特布他林雾化治疗 72 小时。该病例表明,在秋冬季节,取消强制性口罩等防疫措施存在潜在风险。此外,这也突显了在后 COVID-19 时代可能面临的挑战,因为仅依赖流感疫苗可能还不够。

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Coinfection by influenza A virus and respiratory syncytial virus produces hybrid virus particles.
甲型流感病毒和呼吸道合胞病毒的合并感染会产生杂交病毒颗粒。
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BMC Infect Dis. 2022 Sep 29;22(1):759. doi: 10.1186/s12879-022-07745-0.
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First case of monkeypox virus, SARS-CoV-2 and HIV co-infection.首例猴痘病毒、严重急性呼吸综合征冠状病毒2型和人类免疫缺陷病毒合并感染病例。
J Infect. 2023 Jan;86(1):e21-e23. doi: 10.1016/j.jinf.2022.08.014. Epub 2022 Aug 19.
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