Department Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands.
Department Biomolecular Health Sciences, Utrecht University, Utrecht, The Netherlands.
Adv Microb Physiol. 2023;82:129-154. doi: 10.1016/bs.ampbs.2022.10.001. Epub 2022 Nov 11.
Lysophospholipids (LPLs) are lipid-derived metabolic intermediates in the cell membrane. The biological functions of LPLs are distinct from their corresponding phospholipids. In eukaryotic cells LPLs are important bioactive signaling molecules that regulate many important biological processes, but in bacteria the function of LPLs is still not fully defined. Bacterial LPLs are usually present in cells in very small amounts, but can strongly increase under certain environmental conditions. In addition to their basic function as precursors in membrane lipid metabolism, the formation of distinct LPLs contributes to the proliferation of bacteria under harsh circumstances or may act as signaling molecules in bacterial pathogenesis. This review provides an overview of the current knowledge of the biological functions of bacterial LPLs including lysoPE, lysoPA, lysoPC, lysoPG, lysoPS and lysoPI in bacterial adaptation, survival, and host-microbe interactions.
溶血磷脂（LPLs）是细胞膜中脂质衍生的代谢中间产物。LPLs 的生物学功能与其相应的磷脂不同。在真核细胞中，LPLs 是重要的生物活性信号分子，调节许多重要的生物学过程，但在细菌中，LPLs 的功能尚未完全确定。细菌 LPLs 通常在细胞中以非常低的量存在，但在某些环境条件下可以强烈增加。除了作为膜脂代谢前体的基本功能外，特定 LPLs 的形成有助于细菌在恶劣环境下的增殖，或者可以作为细菌发病机制中的信号分子发挥作用。本综述概述了细菌 LPLs（包括溶血磷脂酰乙醇胺、溶血磷脂酰丝氨酸、溶血磷脂酰胆碱、溶血磷脂酸、溶血磷脂酰肌醇）在细菌适应、存活和宿主-微生物相互作用中的生物学功能的最新知识。
