Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China.
Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
BMJ Open. 2020 Sep 10;10(9):e024646. doi: 10.1136/bmjopen-2018-024646.
To assess the prevalence of cerebral stroke in the general population of Beijing and its association with systemic risk factors and ocular diseases.
The population-based Beijing Eye Study was conducted in a rural and urban region of Beijing.
With eligibility criteria of age 50+ years and living in the study regions, 3468 subjects (78.8%) out of 4403 eligible individuals participated.
The study participants underwent a detailed systemic and ophthalmological examination and an interview in which the occurrence of a previous stroke was assessed.
A previous stroke was reported by 235 individuals (7.33%; 95% CI 6.43% to 8.24%). The prevalence of previous stroke increased from 2.0% (95% CI 0.9% to 3.1%) in the age group of 50 to <55 years to 21.9% (95% CI 16.4% to 27.4%) in the age group of 80+ years. In multivariable regression analysis, a higher prevalence of previous stroke was correlated (Nagelkerke R=0.20) with the systemic parameters of older age (p<0.001; OR 1.06; 95% CI 1.04 to 1.08), male gender (p<0.001; OR 0.54; 95% CI 0.40 to 0.74), lower quality of life score (p<0.001; OR 1.39; 95% CI 1.25 to 1.55), higher prevalence of arterial hypertension (p<0.001; OR 2.86; 95% CI 2.05 to 3.98), and cardiovascular disease (p<0.001; OR 1.8554; 95% CI 1.34 to 2.56), and with the ocular parameter of higher prevalence of diabetic retinopathy (p<0.001; OR 4.41; 95% CI 2.38 to 8.18) or alternatively, with higher stage of diabetic retinopathy (p<0.001; OR 1.64; 95% CI 1.26 to 2.14).
In this North Chinese population aged 50+ years, the prevalence of a previous stroke was 7.33% (95% CI 6.43% to 8.24%). After adjusting for systemic risk factors of older age, male gender and higher prevalence of arterial hypertension and cardiovascular disease, a higher prevalence of a previous stroke was significantly correlated with a higher prevalence and stage of diabetic retinopathy. The prevalence of a previous stroke increased for each step of an increase in the stage of diabetic retinopathy with an OR of 1.64 (95% CI 1.26 to 2.14), and it increased by the presence of diabetic retinopathy with an OR of 4.41 (95% CI 2.38 to 8.18).
评估北京一般人群中脑卒中和全身性风险因素及眼部疾病的相关性。
该研究为基于人群的北京眼研究，在北京市的城乡地区进行。
3468 名符合条件的个体（年龄 50 岁及以上，居住在研究地区）中有 3468 名（78.8%）参与了该研究。
研究参与者接受了详细的系统和眼科检查以及访谈，评估了既往卒中的发生情况。
235 名个体（7.33%；95%CI 6.43%至 8.24%）报告了既往卒中。既往卒中的患病率从 50 岁至<55 岁年龄组的 2.0%（95%CI 0.9%至 3.1%）上升到 80 岁及以上年龄组的 21.9%（95%CI 16.4%至 27.4%）。多变量回归分析显示，既往卒中的高患病率与年龄较大（Nagelkerke R=0.20；p<0.001；OR 1.06；95%CI 1.04 至 1.08）、男性（p<0.001；OR 0.54；95%CI 0.40 至 0.74）、生活质量评分较低（p<0.001；OR 1.39；95%CI 1.25 至 1.55）、高血压患病率较高（p<0.001；OR 2.86；95%CI 2.05 至 3.98）和心血管疾病（p<0.001；OR 1.8554；95%CI 1.34 至 2.56）显著相关，与眼部参数中糖尿病视网膜病变的高患病率（p<0.001；OR 4.41；95%CI 2.38 至 8.18）或更高的糖尿病视网膜病变分期（p<0.001；OR 1.64；95%CI 1.26 至 2.14）也显著相关。
在该北京北地区 50 岁及以上人群中，既往卒中的患病率为 7.33%（95%CI 6.43%至 8.24%）。在校正了年龄较大、男性和高血压及心血管疾病等全身性危险因素后，既往卒中的高患病率与糖尿病视网膜病变的高患病率和较高分期显著相关。糖尿病视网膜病变分期每增加一级，既往卒中的比值比（OR）为 1.64（95%CI 1.26 至 2.14），有糖尿病视网膜病变者的 OR 为 4.41（95%CI 2.38 至 8.18）。
