Rappoldt Lotte R, van der Pol Marthe M, de Wit Carola, Slaghekke Simone, Houben Caroline, Sondaar Tom, Kan Kees J, van Steensel Francisca J A Bonny, Denys Damiaan, Vulink Nienke C C, Utens Elisabeth M W J
Amsterdam UMC Location University of Amsterdam, Department of Psychiatry, Amsterdam, the Netherlands.
Academic Center for Child and Adolescent Psychiatry Levvel, Amsterdam, the Netherlands.
Contemp Clin Trials Commun. 2023 Mar 11;33:101105. doi: 10.1016/j.conctc.2023.101105. eCollection 2023 Jun.
Misophonia is a recently identified disorder in which individuals experience intense, uncontrollable and disproportional irritation, anger or disgust when confronted with specific sounds or stimuli associated with these sounds. Prevalence rates in children and adolescents are currently still to be investigated. The reported average age of onset is around 13 years, in clinical practice children from 8 years old are referred.Misophonia is associated with avoidance and anticipation anxiety, possibly leading to serious educational and social consequences for children and families. Worldwide, no evidence-based treatment exists specifically for children and adolescents with misophonia.This article presents the design of a randomized controlled trial testing the effectiveness of cognitive behavioral therapy (CBT) combined with psychomotor therapy (PMT) for misophonia in children and adolescents (aged 8-18).
In total, 82 patients will be randomly assigned to a treatment condition or waiting list condition of 3 months (WCG). Treatment consists of 7 weekly group therapy sessions (1.5 h CBT plus 1.5 h PMT) and a follow-up after 3 weeks. Pre and post treatment assessments will be conducted during a baseline assessment, after 3 and 6 months. The primary outcome will be assessed by the Amsterdam Misophonia Scale - Youth (AMISOS-Y) and secondary outcomes (e.g. quality of life) and putative predictors (e.g. parenting burden) will be studied.
This trial is the first study worldwide testing the effectiveness of a combined CBT plus PMT protocol for misophonia in children and adolescents. If proven effective, this protocol provides an innovation to improve care for youth with misophonia.
恐音症是一种最近才被确认的疾病，患者在面对特定声音或与这些声音相关的刺激时，会产生强烈、无法控制且不成比例的烦躁、愤怒或厌恶情绪。儿童和青少年的患病率目前仍有待研究。报告的平均发病年龄约为13岁，在临床实践中，8岁的儿童也会前来就诊。恐音症与回避和预期焦虑有关，可能会给儿童及其家庭带来严重的教育和社会后果。在全球范围内，尚无专门针对患有恐音症的儿童和青少年的循证治疗方法。本文介绍了一项随机对照试验的设计，该试验旨在测试认知行为疗法（CBT）与心理运动疗法（PMT）相结合对8至18岁儿童和青少年恐音症的疗效。
总共82名患者将被随机分配到治疗组或为期3个月的等待列表组（WCG）。治疗包括每周7次的团体治疗课程（1.5小时CBT加1.5小时PMT）以及3周后的随访。在基线评估期间、3个月和6个月后进行治疗前和治疗后的评估。主要结局将通过阿姆斯特丹青少年恐音症量表（AMISOS-Y）进行评估，并将研究次要结局（如生活质量）和假定预测因素（如育儿负担）。
该试验是全球首个测试CBT与PMT联合方案对儿童和青少年恐音症疗效的研究。如果被证明有效，该方案将为改善对患有恐音症的青少年的护理提供创新方法。
