Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
Faculty of Pharmacy, Memorial University of Newfoundland, St John's, Newfoundland and Labrador, Canada.
PLoS One. 2023 Mar 23;18(3):e0271079. doi: 10.1371/journal.pone.0271079. eCollection 2023.
Canada was one of the first countries to regulate the medical use of cannabis. However, literature on Canada's medical cannabis program is limited.
We use administrative data from the medical cannabis program, and licensed cannabis vendor catalog data to describe a) the participation of patients, physicians, and cannabis vendors in the program from its inception in 1999 to 2021, and b) trends in medical cannabis consumption, prices and potency. We also use national surveys conducted over the last several decades to estimate trends in regular cannabis use (medical or otherwise) and how it changed during the medical cannabis access regimes.
In 2001, the Canadian government granted access to those with physician-documented evidence of a severe health problem that could not be managed using conventional therapies. Most patients accessed cannabis grown under a personal production license. By 2013, authorized daily cannabis dosages were very high. In 2014, the government, concerned over illegal diversion, required that cannabis be purchased from a licensed commercial grower; personal production was banned. Physicians were given responsibility for authorizing patient access. To fill the regulatory void, the physician regulatory bodies in Canada imposed their own prescribing restrictions. After these changes, the number of physicians who were willing to support patient cannabis use markedly decline but the number of patients participating in the program sharply increased. Medical cannabis use varied by province-rates were generally lower in provinces with stricter regulations on physician cannabis prescribing. Most varieties of cannabis oil available for sale are now high in CBD and low in THC. Dry cannabis varieties, conversely, tend to be high in THC and low in CBD. Inflation adjusted prices of most varieties of medical cannabis have declined over time. We find that rates of daily cannabis use (medical or otherwise) increased markedly after the 2014 policy regime. The fraction of Canadians using cannabis daily increased again after the 2018 legalization of recreational cannabis; at the same time, participation in the medical access program declined.
The implications for patient health outcomes of changes in the medical cannabis program and legalization of recreational use remains an important area for future research.
加拿大是最早规范医用大麻使用的国家之一。然而,有关加拿大医用大麻计划的文献有限。
我们使用医用大麻计划的行政数据和持牌大麻供应商目录数据,描述 a) 自 1999 年该计划启动以来,患者、医生和大麻供应商的参与情况,以及 b) 医用大麻消费、价格和效力的趋势。我们还使用过去几十年进行的全国性调查来估计常规大麻使用(医用或其他)的趋势,以及在医用大麻准入制度期间它是如何变化的。
2001 年,加拿大政府允许那些有医生证明患有严重健康问题且无法通过常规疗法治疗的人使用医用大麻。大多数患者使用个人生产许可证生产的大麻。到 2013 年,授权的每日大麻剂量非常高。2014 年,政府担心非法转移,要求从持牌商业种植者处购买大麻;个人生产被禁止。医生被赋予授权患者使用医用大麻的责任。为了填补监管空白,加拿大的医生监管机构对自己的处方限制施加了限制。这些变化之后,愿意支持患者使用医用大麻的医生数量明显下降,但参与该计划的患者数量急剧增加。医用大麻的使用因省份而异——在对医生开具医用大麻处方限制更严格的省份,使用率通常较低。可销售的大麻油品种大多 CBD 含量高,THC 含量低。相反,干大麻品种 THC 含量高,CBD 含量低。经过通胀调整,大多数品种的医用大麻价格都呈下降趋势。我们发现,2014 年政策制度实施后,每日大麻使用(医用或其他)的比率显著增加。2018 年娱乐用大麻合法化后,每天使用大麻的加拿大人比例再次上升;与此同时,参与医用准入计划的人数下降。
医用大麻计划的变化和娱乐用大麻合法化对患者健康结果的影响仍然是未来研究的一个重要领域。