Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran.
Physiology Research center, Institute of Neuropharmacology, and Department of Nutrition, Faculty of Public Health, Kerman University of Medical Sciences, Kerman, Iran.
Nutr Cancer. 2023;75(2):402-414. doi: 10.1080/01635581.2022.2129080. Epub 2022 Oct 10.
Cancer is the second leading cause of death in the world. Reports on the effect of Trimethylamine-N-oxide (TAMO), a small amine oxide generated by gut microbial metabolism of choline, betaine, and carnitine, on cancer are inconsistent. Therefore, this systematic review and meta-analysis summarize the effect of TAMO on cancer incidence. A systematic search was conducted in PubMed, Scopus, Web of Science, and Embase. Data were pooled using the random-effects method and were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). The pooled results of 16 studies, including 5930 participants, showed that the association between TMAO levels and cancer incidence is insignificant (Odds Ratio: 0.97, 95% CI: (0.64, 1.46), -value = 0.871). Subgroup analysis showed that urinary TMAO levels were negatively associated with cancer incidence; in contrast, a direct and positive association was observed between serum TMAO levels and cancer incidence. However, "gender" and the "TMAO measuring method" were the potential sources of discrepancies. Meta-regression analysis did not reveal any significant association between duration of studies, age, female ratio, subjects-control, and subjects-case. The present study demonstrates that serum TAMO levels were insignificantly associated with cancer incidence.
癌症是世界上第二大致死原因。关于肠道微生物代谢胆碱、甜菜碱和肉碱产生的小胺氧化物三甲胺-N-氧化物（TAMO）对癌症的影响的报告结果不一致。因此，本系统评价和荟萃分析总结了 TAMO 对癌症发病率的影响。在 PubMed、Scopus、Web of Science 和 Embase 中进行了系统检索。使用随机效应方法汇总数据，并表示为加权均数差（WMD）和 95%置信区间（CI）。16 项研究共 5930 名参与者的汇总结果表明，TMAO 水平与癌症发病率之间的关联并不显著（优势比：0.97，95%CI：（0.64，1.46），P 值=0.871）。亚组分析表明，尿 TMAO 水平与癌症发病率呈负相关；相比之下，血清 TMAO 水平与癌症发病率呈直接正相关。然而，“性别”和“TMAO 测量方法”是差异的潜在来源。元回归分析未发现研究持续时间、年龄、女性比例、病例对照和病例组间有任何显著关联。本研究表明，血清 TAMO 水平与癌症发病率无显著关联。
