Quantitative Diagnostic Imaging, Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics, Course of Applied Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata, Niigata, Japan.
Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan.
Dentomaxillofac Radiol. 2020 Dec 1;49(8):20200043. doi: 10.1259/dmfr.20200043. Epub 2020 Jun 15.
To investigate the assessment of inflammatory jaw pathologies using bone single-photon emission CT-CT (SPECT/CT) maximum standardized uptake value (SUV).
44 patients with inflammatory jaw pathologies (7 chronic osteomyelitis, 8 osteoradionecrosis and 29 medication-related osteonecrosis of the jaw (MRONJ)) underwent SPECT/CT at 4 h after injection of Tc hydroxymethylene diphosphonate. The SPECT/CT parameters SUV of the inflammatory jaw pathologies were analyzed. Statistical analyses for the SUV were performed by one-way repeated measures analysis of variance with Tukey's honestly significant difference test. A -value lower than 0.05 was considered statistically significant.
The mean and standard deviation of SUV for 7 chronic osteomyelitis, 8 osteoradionecrosis and 29 MRONJ were 24.94 ± 3.65, 12.27 ± 5.47 and 16.55 ± 9.12, respectively. The SUV for chronic osteomyelitis were significantly higher than those for osteoradionecrosis ( = 0.011) and MRONJ ( = 0.043).
Bone SPECT/CT SUV in the uptake of Tc hydroxymethylene diphosphonate reflecting bone physiological changes for chronic osteomyelitis were significantly higher than those of osteonecrosis, such as osteoradionecrosis and MRONJ. Bone SPECT/CT SUV should be useful for the assessment of inflammatory jaw pathologies, such as chronic osteomyelitis, osteoradionecrosis and MRONJ.
利用骨单光子发射 CT-CT（SPECT/CT）最大标准化摄取值（SUV）评估炎性颌骨病变。
44 例炎性颌骨病变患者（7 例慢性骨髓炎、8 例放射性骨坏死和 29 例药物相关性颌骨坏死（MRONJ））在注射 Tc 羟甲基二膦酸盐后 4 小时行 SPECT/CT 检查。分析炎性颌骨病变的 SPECT/CT 参数 SUV。采用单因素重复测量方差分析和 Tukey Honestly Significant Difference 检验进行 SUV 统计分析。p 值小于 0.05 为有统计学意义。
7 例慢性骨髓炎、8 例放射性骨坏死和 29 例 MRONJ 的 SUV 平均值和标准差分别为 24.94±3.65、12.27±5.47 和 16.55±9.12。慢性骨髓炎的 SUV 明显高于放射性骨坏死（p=0.011）和 MRONJ（p=0.043）。
Tc 羟甲基二膦酸盐摄取反映慢性骨髓炎骨生理变化的 SPECT/CT SUV 明显高于放射性骨坏死和 MRONJ。SPECT/CT SUV 可用于评估慢性骨髓炎、放射性骨坏死和 MRONJ 等炎性颌骨病变。
