血浆烷基间苯二酚代谢物，一种全谷物摄入量的生物标志物，在一项中国成年人病例对照研究中与非酒精性脂肪性肝病风险呈负相关。

Plasma Alkylresorcinol Metabolite, a Biomarker for Whole-Grain Intake, Is Inversely Associated with Risk of Nonalcoholic Fatty Liver Disease in a Case-Control Study of Chinese Adults.

作者信息

Sun Taoping, Deng Yao, Geng Xuyang, Fang Qin, Li Xiaoqin, Chen Liangkai, Zhan Meixiao, Li Deyun, Zhu Kejing, Li Huawen, Liu Liegang

机构信息

Department of Nutrition and Food Hygiene, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Zhuhai Precision Medical Center, Zhuhai Interventional Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, China.

Zhuhai Precision Medical Center, Zhuhai Interventional Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, China.

出版信息

J Nutr. 2022 Apr;152(4):1052-1058. doi: 10.1093/jn/nxab404. Epub 2023 Feb 18.

DOI:10.1093/jn/nxab404

PMID:36967162

Abstract

BACKGROUND

Epidemiologic studies consistently find associations between whole-grain intake and reduced risk of obesity and related metabolic diseases, yet data on the potential of whole grains to prevent fatty liver diseases are scarce.

OBJECTIVES

To examine whether plasma 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), a biomarker of whole-grain wheat and rye intake, is associated with nonalcoholic fatty liver disease (NAFLD).

METHODS

This case-control study of Chinese adults enrolled 940 NAFLD cases and 940 age- and sex-matched non-NAFLD controls (mean age: 55.2 y; 65% males). NAFLD diagnosis was defined as individuals whose hepatic ultrasound disclosed hepatic steatosis at any stage, after the exclusion of alcohol abuse and other liver diseases. Fasting plasma DHPPA concentration was measured by LC-MS/MS. Multivariate adjusted ORs and 95% CIs were estimated to assess the association between plasma DHPPA and NAFLD using conditional logistic regression.

RESULTS

Plasma concentration of DHPPA was significantly lower in patients with NAFLD compared with controls (median: 9.86 nmol/L compared with 10.9 nmol/L, P = 0.002). In multivariable logistic regression models, the ORs (95% CIs) for NAFLD across increasing tertiles of plasma DHPPA were 1 (reference), 0.76 (0.54, 1.05), and 0.65 (0.45, 0.93), respectively (P-trend = 0.026). In addition, the inverse associations persisted in subgroups stratified by sex, age, BMI, abdominal adiposity, smoking status, physical activity, diabetes, hypertension, and hyperlipidemia.

CONCLUSIONS

These results indicate that increased plasma DHPPA concentration is associated with lower risk of NAFLD in Chinese adults, independently of well-known risk factors. Our finding provides evidence to support health benefits of whole-grain consumption on NAFLD. This trial was registered at clinicaltrials.gov as NCT03845868.

摘要

背景

流行病学研究一致发现全谷物摄入量与肥胖及相关代谢疾病风险降低之间存在关联，但关于全谷物预防脂肪肝疾病潜力的数据却很稀少。

目的

研究血浆3-(3,5-二羟基苯基)-1-丙酸（DHPPA），一种全谷物小麦和黑麦摄入量的生物标志物，是否与非酒精性脂肪性肝病（NAFLD）相关。

方法

这项针对中国成年人的病例对照研究纳入了940例NAFLD病例和940例年龄及性别匹配的非NAFLD对照（平均年龄：55.2岁；65%为男性）。NAFLD的诊断定义为在排除酒精滥用和其他肝脏疾病后，肝脏超声显示处于任何阶段肝脂肪变性的个体。采用液相色谱-串联质谱法测量空腹血浆DHPPA浓度。使用条件逻辑回归估计多变量调整后的OR值和95%CI，以评估血浆DHPPA与NAFLD之间的关联。

结果

与对照组相比，NAFLD患者的血浆DHPPA浓度显著降低（中位数：9.86 nmol/L对比10.9 nmol/L，P = 0.002）。在多变量逻辑回归模型中，随着血浆DHPPA三分位数的增加，NAFLD的OR值（95%CI）分别为1（参考值）、0.76（0.54, 1.05）和0.65（0.45, 0.93）（P趋势 = 0.026）。此外，在按性别、年龄、BMI、腹部肥胖、吸烟状况、身体活动、糖尿病、高血压和高脂血症分层的亚组中，这种负相关关系依然存在。