Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety.
Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Am J Clin Nutr. 2019 Feb 1;109(2):1-7. doi: 10.1093/ajcn/nqy323.
Epidemiologic studies on whole grains and risk of stroke have reported inconsistent results, with some suggesting a protective effect but others showing a null association.
The aim of this study was to examine whether plasma 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), a biomarker of whole-grain wheat and rye intake, is associated with risk of ischemic stroke.
A hospital-based case-control study was conducted between March 2011 and May 2016. Cases (n = 990) with first ischemic stroke were matched to controls (n = 990) by sex and age. Concentrations of plasma DHPPA were determined by high-performance liquid chromatography-tandem mass spectrometry. We calculated ORs for the association of plasma DHPPA concentrations with ischemic stroke risk through the use of logistic regression.
Plasma DHPPA was inversely associated with ischemic stroke risk. After adjustment for potential confounding factors, the ORs for ischemic stroke across increasing quartiles of plasma DHPPA concentrations were 1 (referent), 0.76 (95% CI: 0.58, 0.99), 0.71 (95% CI: 0.54, 0.92), and 0.59 (95% CI: 0.45, 0.77), respectively (P-trend = 0.001). The inverse association was also observed in all subgroups of participants according to sex, age, body mass index, smoking status, alcohol consumption, history of hypertension, and history of diabetes.
Our study showed that higher plasma DHPPA concentrations were associated with lower risk of ischemic stroke. This finding provides further evidence to support the health benefits of whole-grain consumption.
全谷物与中风风险的流行病学研究结果不一致，一些研究表明存在保护作用，而另一些则显示为无关联。
本研究旨在探讨血浆 3-(3,5-二羟苯基)-1-丙酸（DHPPA），一种全谷物小麦和黑麦摄入的生物标志物，与缺血性中风风险之间是否存在关联。
本研究采用病例对照研究设计，于 2011 年 3 月至 2016 年 5 月期间进行。病例（n=990）为首次发生缺血性中风的患者，通过性别和年龄与对照组（n=990）进行匹配。采用高效液相色谱-串联质谱法测定血浆 DHPPA 浓度。通过 logistic 回归计算血浆 DHPPA 浓度与缺血性中风风险之间的比值比（OR）。
血浆 DHPPA 与缺血性中风风险呈负相关。在调整潜在混杂因素后，血浆 DHPPA 浓度递增 quartiles 与缺血性中风风险的 OR 分别为 1（参照）、0.76（95%CI：0.58，0.99）、0.71（95%CI：0.54，0.92）和 0.59（95%CI：0.45，0.77）（P-trend=0.001）。这种负相关在根据性别、年龄、体重指数、吸烟状况、饮酒状况、高血压史和糖尿病史进行的所有亚组参与者中也观察到。
本研究表明，较高的血浆 DHPPA 浓度与较低的缺血性中风风险相关。这一发现为全谷物摄入对健康的益处提供了进一步的证据支持。
