2001-2018 年美国成年人中风或心肌梗死幸存者的血脂谱和血脂控制趋势。
Trends in lipid profile and lipid control among survivors of stroke or myocardial infarction among US adults, 2001-2018.
机构信息
Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, China.
出版信息
Front Endocrinol (Lausanne). 2023 Mar 8;14:1128878. doi: 10.3389/fendo.2023.1128878. eCollection 2023.
BACKGROUND
We aim to analyze the change in lipid profile and lipid control among survivors of stroke and/or myocardial infarction among US adults from 2001-2018.
METHODS
In total, 3,736 survivors of stroke and/or myocardial infarction from the 2001-2018 National Health and Nutrition Examination Surveys were included in this study, representing a weighted total population of 110,005,898. Trends for lipid concentration and lipid control rate over time were detected general linear regression analysis and lipid control was compared by sex and race survey-weighted logistic regression analysis.
RESULTS
The total cholesterol, LDL, and triglyceride concentrations were significantly decreased in survivors from the 2001-2002 survey cycle to the 2017-2018 survey cycle (p for trend < 0.01). Lipid control was defined as total cholesterol < 200 mg/dL. Among survivors, the lipid control rate increased from 56.2% (95% CI: 43.9%, 67.7%) in the 2001-2002 survey cycle to 73.2% (95% CI: 64.8%, 80.2%) in the 2017-2018 survey cycle (p for trend < 0.01). Women had a higher lipid concentration and were more likely have poor lipid control compared to men. Non-Hispanic White survivors possessed better lipid control than other races survivors.
CONCLUSIONS
Lipid concentrations decreased and lipid control improved in stroke and/or myocardial infarction survivors from 2001 to 2018, with heterogeneity observed according to sex and race.
背景
本研究旨在分析 2001 年至 2018 年期间美国成年人中风和/或心肌梗死幸存者的血脂谱和血脂控制变化情况。
方法
本研究共纳入 3736 名中风和/或心肌梗死幸存者，他们来自 2001 年至 2018 年的国家健康和营养调查，代表了 11005898 人的加权总人口。通过一般线性回归分析检测血脂浓度和血脂控制率随时间的变化趋势，并通过调查加权逻辑回归分析比较性别和种族之间的血脂控制情况。
结果
总胆固醇、LDL 和甘油三酯浓度在 2001 年至 2002 年调查周期至 2017 年至 2018 年调查周期的幸存者中显著降低（趋势 p<0.01）。血脂控制定义为总胆固醇<200mg/dL。在幸存者中，血脂控制率从 2001 年至 2002 年调查周期的 56.2%（95%可信区间：43.9%，67.7%）增加到 2017 年至 2018 年调查周期的 73.2%（95%可信区间：64.8%，80.2%）（趋势 p<0.01）。与男性相比，女性的血脂浓度更高，血脂控制不良的可能性更大。与其他种族的幸存者相比，非西班牙裔白种幸存者的血脂控制更好。
结论
2001 年至 2018 年，中风和/或心肌梗死幸存者的血脂浓度降低，血脂控制改善，但根据性别和种族存在异质性。
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