Menon Parvathy Mohan, Chandrasekaran Natarajan, C George Priya Doss, Shanmugam Sivakumar
Department of Integrative Biology, School of Bioscience and Technology, Vellore Institute of Technology Vellore India
Centre for Nanobiotechnology, Vellore Institute of Technology Vellore India
RSC Med Chem. 2023 Jan 19;14(3):433-443. doi: 10.1039/d2md00320a. eCollection 2023 Mar 22.
Tuberculosis is one of the oldest bacterial infections known to mankind caused by . The aim of this research is to optimize and formulate a multi-drug loaded eugenol based nanoemulsion system and to evaluate its ability as an antimycobacterial agent and its potential to be a low cost and effective drug delivery system. All the three eugenol based drug loaded nano-emulsion systems were optimized using response surface methodology (RSM)-central composite design (CCD) and were found stable at a ratio of 1 : 5 (oil : surfactant) when ultrasonicated for 8 minutes. The minimum inhibitory concentration (MIC) values against strains of highly proved that these essential oil-based nano-emulsions showed more promising results and an even improved anti-mycobacterium activity on the addition of a combination of drugs. The absorbance of 1st line anti-tubercular drugs from release kinetics studies showed a controlled and sustained release in body fluids. Thus, we can conclude that this is a much more efficient and desirable method in treating infections caused by and even its MDR/XDR strains. All these nano-emulsion systems were stable for more than 3 months.
结核病是人类已知的最古老的细菌感染之一，由……引起。本研究的目的是优化并制备一种载有多药的丁香酚基纳米乳剂系统，并评估其作为抗分枝杆菌剂的能力以及成为低成本有效药物递送系统的潜力。所有三种基于丁香酚的载药纳米乳剂系统均采用响应面法（RSM）-中心复合设计（CCD）进行优化，超声处理8分钟后，发现其在1:5（油:表面活性剂）的比例下稳定。对……菌株的最低抑菌浓度（MIC）值有力地证明，这些基于精油的纳米乳剂显示出更有前景的结果，并且在添加药物组合后抗分枝杆菌活性有所提高。释放动力学研究中一线抗结核药物的吸光度表明其在体液中可控且持续释放。因此，我们可以得出结论，这是治疗由……及其耐多药/广泛耐药菌株引起的感染的一种更有效且理想的方法。所有这些纳米乳剂系统在3个月以上均保持稳定。
