Guo Rui, Chen Heyu, Yang Yang
Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA 93106, USA.
Biomolecular Science and Engineering (BMSE) Program, University of California Santa Barbara, Santa Barbara, CA 93106, USA.
Nat Catal. 2022 Jul;5(7):582-583. doi: 10.1038/s41929-022-00813-3. Epub 2022 Jul 22.
General catalytic methods for free radical-mediated asymmetric transformations have long eluded synthetic organic chemists. Now, NAD(P)H-dependent ketoreductases (KREDs) are repurposed and engineered as highly efficient photoenzymes to catalyse asymmetric radical C-C couplings.
自由基介导的不对称转化的通用催化方法长期以来一直困扰着有机合成化学家。现在，依赖烟酰胺腺嘌呤二核苷酸（磷酸）（NAD(P)H）的酮还原酶（KREDs）被重新利用并设计成高效的光酶，以催化不对称自由基碳-碳偶联反应。
