Hamidi Shabnam, Zarnke Sasha, Turcotte Kim, Silver Samuel A
Division of Nephrology, Department of Medicine, Queen's University, Kingston, ON, Canada.
Kingston Health Sciences Centre, ON, Canada.
Can J Kidney Health Dis. 2023 Mar 20;10:20543581231162235. doi: 10.1177/20543581231162235. eCollection 2023.
Patients with end-stage kidney disease face high mortality and morbidity after dialysis initiation. Transitional care units (TCUs) are typically 4- to 8-week structured multidisciplinary programs targeted toward patients starting hemodialysis during this high-risk time in their care. The goals of such programs are to provide psychosocial support, provide dialysis modality education, and reduce risks of complications. Despite apparent benefits, the TCU model may be challenging to implement, and the effect on patient outcomes is unclear.
To assess a newly created multidisciplinary TCUs' feasibility for patients newly started on hemodialysis.
Before-and-after study.
Kingston Health Sciences Centre hemodialysis unit in Ontario, Canada.
We considered all adult patients (age 18+) who initiated in-center maintenance hemodialysis eligible for the TCU program, although patients on infection control precautions and evening shifts were not able to receive TCU care due to staffing limitations.
We defined feasibility as eligible patients completing the TCU program in a timely fashion without additional need for space, no signal of harm, and without explicit concerns from TCU staff or patients at weekly meetings. Key outcomes at 6 months included mortality, proportion hospitalized, dialysis modality, vascular access, initiation of transplant workup, and code status.
The TCU care consisted of 1:1 nursing and education until predefined clinical stability and dialysis decisions were satisfied. We compared outcomes among the pre-TCU cohort who initiated hemodialysis between June 2017 and May 2018, and TCU patients who initiated dialysis between June 2018 and March 2019. We summarized outcomes descriptively, along with unadjusted odds ratios (ORs) and 95% confidence intervals (CIs).
We included 115 pre-TCU patients and 109 post-TCU patients, of whom 49/109 (45%) entered and completed the TCU. The most common reasons for not participating in the TCU included evening hemodialysis shifts (18/60, 30%) or contact precautions (18/60, 30%). The TCU patients completed the program in a median of 35 (25-47) days. We observed no differences in mortality (9% vs 8%; OR = 0.93, 95% CI = 0.28-3.13) or proportion hospitalized (38% vs 39%; OR = 1.02, 95% CI = 0.51-2.03) between the pre-TCU cohort and TCU patients. There was also no difference in use of home dialysis (16% vs 10%; OR = 1.67, 95% CI = 0.64-4.39), non-catheter access (32% vs 25%; OR = 1.44, 95% CI = 0.69-2.98), initiation of transplant workup (14% vs 12%; OR 1.67; 95% CI = 0.64-4.39), and choosing "do not resuscitate" (DNR) orders (22% vs 19%; OR = 1.22, 95% CI = 0.54-2.77). There was no negative patient or staff feedback on the program.
Small sample size and potential for selection bias given inability to provide TCU care for patients on infection control precautions or evening shifts.
The TCU accommodated a large number of patients, who completed the program in a timely fashion. The TCU model was determined to be feasible at our center. There was no difference in outcomes due to the small sample size. Future work at our center is required to expand the number of TCU dialysis chairs to evening shifts and evaluate the TCU model in prospective, controlled studies.
终末期肾病患者在开始透析后面临较高的死亡率和发病率。过渡护理单元(TCU)通常是为期4至8周的结构化多学科项目,针对处于护理高风险期开始血液透析的患者。此类项目的目标是提供心理社会支持、进行透析方式教育并降低并发症风险。尽管有明显益处,但TCU模式可能难以实施,且对患者结局的影响尚不清楚。
评估新设立的多学科TCU对新开始血液透析患者的可行性。
前后对照研究。
加拿大安大略省金斯顿健康科学中心血液透析单元。
我们将所有开始中心维持性血液透析且符合TCU项目条件的成年患者(年龄18岁及以上)纳入研究,不过由于人员配备限制,采取感染控制预防措施的患者和值晚班的患者无法接受TCU护理。
我们将可行性定义为符合条件的患者及时完成TCU项目,无需额外空间,无伤害信号,且TCU工作人员或患者在周会上无明确担忧。6个月时的主要结局包括死亡率、住院比例、透析方式、血管通路、启动移植评估以及代码状态。
TCU护理包括一对一护理和教育,直至达到预先定义的临床稳定性并满足透析决策。我们比较了2017年6月至2018年5月开始血液透析的TCU前队列患者与2018年6月至2019年3月开始透析的TCU患者的结局。我们对结局进行了描述性总结,并给出未调整的优势比(OR)和95%置信区间(CI)。
我们纳入了115名TCU前患者和109名TCU后患者,其中109名中的49名(45%)进入并完成了TCU项目。未参与TCU的最常见原因包括晚班血液透析(18/60,30%)或接触预防措施(18/60,30%)。TCU患者完成项目的中位时间为35(25 - 47)天。我们观察到TCU前队列患者与TCU患者在死亡率(9%对8%;OR = 0.93,95% CI = 0.28 - 3.13)或住院比例(38%对39%;OR = 1.02,95% CI = 0.51 - 2.03)方面无差异。在家庭透析使用(16%对10%;OR = 1.67,95% CI = 0.64 - 4.39)、非导管通路(32%对25%;OR = 1.44,95% CI = 0.69 - 2.98)、启动移植评估(14%对12%;OR 1.67;95% CI = 0.64 - 4.39)以及选择“不要复苏”(DNR)医嘱(22%对19%;OR = 1.22,95% CI = 0.54 - 2.77)方面也无差异。患者和工作人员对该项目均无负面反馈。
样本量小,且由于无法为采取感染控制预防措施的患者或值晚班的患者提供TCU护理,存在选择偏倚的可能性。
TCU接纳了大量患者,并使他们及时完成了项目。TCU模式在我们中心被确定为可行。由于样本量小,结局无差异。我们中心未来的工作需要将TCU透析椅数量扩展到晚班,并在前瞻性对照研究中评估TCU模式。