Peng Xuan, Yao Siqi, Huang Jing, Zhao Yiming, Chen Hao, Chen Liyu, Yu Zheng
Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China.
Department of Medical Parasitology, School of Basic Medical Science, Central South University, Changsha, China.
Front Microbiol. 2023 Mar 9;14:1138928. doi: 10.3389/fmicb.2023.1138928. eCollection 2023.
Gastric microbiome has been shown to contribute to gastric carcinogenesis, understanding how alterations in gastric microbiome is helpful to the prevention and treatment of gastric cancer (GC). However, few studies have focused on the change of microbiome during the gastric carcinogenesis. In this study, the microbiome of gastric juice samples from healthy control (HC), gastric precancerous lesions (GPL) and gastric cancer (GC) was investigated by 16S rRNA gene sequencing. Our results showed that the alpha diversity of patients with GC was significantly lower than other groups. Compared to other groups, some genera in GC group were shown to be up-regulated (e.g., and ) and down-regulated (e.g., and ). More importantly, the emergence of was closely related to the occurrence and development of GC. Moreover, the microbial interactions and networks in GPL exhibited higher connectivity, complexity and lower clustering property, while GC showed the opposite trend. Taken together, we suggest that changes in the gastric microbiome are associated with GC and perform a key function in maintaining the tumor microenvironment. Therefore, our findings will provide new ideas and references for the treatment of GC.
胃微生物群已被证明与胃癌发生有关，了解胃微生物群的改变如何有助于胃癌（GC）的预防和治疗。然而，很少有研究关注胃癌发生过程中微生物群的变化。在本研究中，通过16S rRNA基因测序对健康对照（HC）、胃癌前病变（GPL）和胃癌（GC）患者的胃液样本中的微生物群进行了研究。我们的结果表明，GC患者的α多样性显著低于其他组。与其他组相比，GC组中的一些属被显示为上调（例如，和）和下调（例如，和）。更重要的是，的出现与GC的发生和发展密切相关。此外，GPL中的微生物相互作用和网络表现出更高的连通性、复杂性和更低的聚集性，而GC则呈现相反的趋势。综上所述，我们认为胃微生物群的变化与GC相关，并在维持肿瘤微环境中发挥关键作用。因此，我们的研究结果将为GC的治疗提供新的思路和参考。
