Ransing Ramdas Sarjerao, Patil Suvarna, Pevekar Krishna, Mishra Kshirod, Patil Bharat
Department of Psychiatry, B K L Walawalkar Rural Medical College, Ratnagiri, India.
Department of Medicine, B K L Walawalkar Rural Medical College, Ratnagiri, India.
Indian J Psychol Med. 2018 Jan-Feb;40(1):68-73. doi: 10.4103/IJPSYM.IJPSYM_139_17.
Mood disorders and psychosis has been reported among the patients with macrocytosis; however, its prevalence among the first episode of psychosis and depression is unknown. The purpose of the study was to establish the prevalence of macrocytosis among the patients with the first episode of depression and psychosis.
In this cross-sectional study, three groups comprising patients with first episode of depression ( = 100), patients with the first episode of psychosis ( = 100), and healthy controls ( = 100) were included. Blood samples were collected from each participant and analyzed using the automated coulter counter. The hematological variables (e.g., macrocytosis, anemia) in the three groups were compared using the Chi-square and analysis of variance tests.
The prevalence of macrocytosis among patients with depression and psychosis was 2.6 (8%) and 3.3 times (11%) higher, respectively than that among the healthy controls (3%). In addition, the hemoglobin concentration, mean corpuscular volume and mean platelet volume in patients with first episodes of psychosis and depression significantly differed from those in healthy controls < 0.001.
This study showed that the prevalence of macrocytosis among the first episode of depression and psychosis was higher than healthy controls. Macrocytosis may have etiological and prognostic significance among these patients. Prospective studies are needed to explore the clinical significance of macrocytosis among the patients with depression and psychosis in the clinical practice.
已有报道称大细胞性贫血患者中存在情绪障碍和精神病；然而，其在首发精神病和抑郁症患者中的患病率尚不清楚。本研究的目的是确定首发抑郁症和精神病患者中大细胞性贫血的患病率。
在这项横断面研究中，纳入了三组人群，分别为首发抑郁症患者（n = 100）、首发精神病患者（n = 100）和健康对照者（n = 100）。采集每位参与者的血样，并使用自动血细胞计数仪进行分析。使用卡方检验和方差分析对三组人群的血液学变量（如大细胞性贫血、贫血）进行比较。
抑郁症患者和精神病患者中大细胞性贫血的患病率分别比健康对照者（3%）高2.6倍（8%）和3.3倍（11%）。此外，首发精神病和抑郁症患者的血红蛋白浓度、平均红细胞体积和平均血小板体积与健康对照者相比有显著差异（P < 0.001）。
本研究表明，首发抑郁症和精神病患者中大细胞性贫血的患病率高于健康对照者。大细胞性贫血在这些患者中可能具有病因学和预后意义。需要进行前瞻性研究以探讨大细胞性贫血在临床实践中抑郁症和精神病患者中的临床意义。
