Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, Alberta, T2N 1N4, Canada.
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, T2N 1N4, Canada.
Adv Healthc Mater. 2023 Aug;12(20):e2203172. doi: 10.1002/adhm.202203172. Epub 2023 May 14.
Currently, the demand for more reliable drug screening devices has made scientists and researchers develop novel potential approaches to offer an alternative to animal studies. Organ-on-chips are newly emerged platforms for drug screening and disease metabolism investigation. These microfluidic devices attempt to recapitulate the physiological and biological properties of different organs and tissues using human-derived cells. Recently, the synergistic combination of additive manufacturing and microfluidics has shown a promising impact on improving a wide array of biological models. In this review, different methods are classified using bioprinting to achieve the relevant biomimetic models in organ-on-chips, boosting the efficiency of these devices to produce more reliable data for drug investigations. In addition to the tissue models, the influence of additive manufacturing on microfluidic chip fabrication is discussed, and their biomedical applications are reviewed.
目前，对更可靠的药物筛选设备的需求促使科学家和研究人员开发新的潜在方法，以替代动物研究。器官芯片是用于药物筛选和疾病代谢研究的新兴平台。这些微流控设备试图用人源细胞来重现不同器官和组织的生理和生物学特性。最近，添加剂制造和微流控技术的协同结合对改进广泛的生物模型显示出了有前景的影响。在这篇综述中，使用生物打印的不同方法被分类以在器官芯片中实现相关的仿生模型，提高这些设备的效率，为药物研究提供更可靠的数据。除了组织模型，还讨论了添加剂制造对微流控芯片制造的影响，并综述了它们的生物医学应用。
