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Reporting NADPH fluxes.

作者信息

Cross Justin R

机构信息

Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

出版信息

Nat Chem Biol. 2023 Jul;19(7):792-794. doi: 10.1038/s41589-023-01298-2.

DOI:10.1038/s41589-023-01298-2
PMID:36973444
Abstract
摘要

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Reporting NADPH fluxes.报告还原型辅酶Ⅱ通量。
Nat Chem Biol. 2023 Jul;19(7):792-794. doi: 10.1038/s41589-023-01298-2.
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The pentose phosphate cycle is regulated by NADPH/NADP ratio in rat liver.磷酸戊糖循环受大鼠肝脏中NADPH/NADP比例的调节。
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Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPH/NADP ratio in rat adipocytes and hepatocytes.胰岛素对大鼠脂肪细胞和肝细胞中磷酸戊糖途径的短期调控可能受NADPH/NADP比值的调节。
Biochem Biophys Res Commun. 1987 Jul 31;146(2):920-5. doi: 10.1016/0006-291x(87)90618-8.
4
The NADPH-producing pathways (pentose phosphate and malic enzyme) are regulated by the NADPH consumption in rat mammary gland.产生NADPH的途径（磷酸戊糖途径和苹果酸酶）受大鼠乳腺中NADPH消耗的调节。
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The NADPH consumption regulates the NADPH-producing pathways (pentose phosphate cycle and malic enzyme) in rat adipocytes.在大鼠脂肪细胞中，NADPH的消耗调节着NADPH生成途径（磷酸戊糖循环和苹果酸酶）。
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Consumption of NADPH for 2-HG Synthesis Increases Pentose Phosphate Pathway Flux and Sensitizes Cells to Oxidative Stress.消耗 NADPH 合成 2-HG 会增加戊糖磷酸途径通量，并使细胞对氧化应激敏感。
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In vivo operation of the pentose phosphate pathway in frog oocytes is limited by NADP+ availability.蛙卵母细胞中磷酸戊糖途径的体内运作受NADP⁺可用性的限制。
FEBS Lett. 1999 Mar 5;446(1):149-52. doi: 10.1016/s0014-5793(99)00192-1.

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本文引用的文献

1
Cytosolic and mitochondrial NADPH fluxes are independently regulated.细胞质和线粒体 NADPH 通量是独立调节的。
Nat Chem Biol. 2023 Jul;19(7):837-845. doi: 10.1038/s41589-023-01283-9. Epub 2023 Mar 27.
2
The "great" controlling nucleotide coenzymes.“伟大的”调控核苷酸辅酶。
IUBMB Life. 2019 May;71(5):565-579. doi: 10.1002/iub.1997. Epub 2019 Jan 9.
3
A genetically encoded tool for manipulation of NADP/NADPH in living cells.一种用于在活细胞中操纵NADP/NADPH的基因编码工具。
Nat Chem Biol. 2017 Oct;13(10):1088-1095. doi: 10.1038/nchembio.2454. Epub 2017 Aug 7.
4
Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells.追踪哺乳动物细胞质和线粒体中隔室化的 NADPH 代谢。
Mol Cell. 2014 Jul 17;55(2):253-63. doi: 10.1016/j.molcel.2014.05.008. Epub 2014 May 29.
5
Quantitative flux analysis reveals folate-dependent NADPH production.定量通量分析揭示了叶酸依赖性 NADPH 的产生。
Nature. 2014 Jun 12;510(7504):298-302. doi: 10.1038/nature13236. Epub 2014 May 4.
6
A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion.一条涉及胞质烟酰胺腺嘌呤二核苷酸磷酸（NADP）依赖性异柠檬酸脱氢酶的丙酮酸循环途径可调节葡萄糖刺激的胰岛素分泌。
J Biol Chem. 2006 Oct 13;281(41):30593-602. doi: 10.1074/jbc.M511908200. Epub 2006 Aug 15.
7
Measuring in vivo metabolism using heavy water.使用重水测量体内代谢。
Curr Opin Clin Nutr Metab Care. 2003 Sep;6(5):511-7. doi: 10.1097/00075197-200309000-00004.
8
Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion.线粒体丙酮酸-苹果酸穿梭在胰岛中的可行性。胞质烟酰胺腺嘌呤二核苷酸磷酸（NADPH）在胰岛素分泌中的进一步意义。
J Biol Chem. 1995 Aug 25;270(34):20051-8.