IgA对人多形核白细胞介导的IgG吞噬作用的抑制
Suppression by IgA of IgG-mediated phagocytosis by human polymorphonuclear leucocytes.
作者信息
Wilton J M
出版信息
Clin Exp Immunol. 1978 Dec;34(3):423-8.
Abstract
IgA from normal human serum, a myeloma IgA and human colostral IgA were found to inhibit the IgG-dependent phagocytosis of (CA) blastospores by polymorphonuclear leucocytes (PMN) from normal human subjects. The inhibition was dependent on the Fc portion of IgA, was enhanced by heat treatment (56°C for 20 min) and depended on binding to the PMN, but not to the opsonized particle. Binding of CA to the PMN IgG Fc receptor was inhibited, whilst the binding to the PMN C3b receptor was unaffected.
摘要
已发现来自正常人血清的IgA、一种骨髓瘤IgA和人初乳IgA可抑制正常人多形核白细胞（PMN）对（CA）芽生孢子的IgG依赖性吞噬作用。这种抑制作用取决于IgA的Fc部分，经热处理（56℃ 20分钟）后增强，且取决于与PMN的结合，但不取决于与调理素化颗粒的结合。CA与PMN IgG Fc受体的结合受到抑制，而与PMN C3b受体的结合未受影响。
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