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Clin Exp Immunol. 1978 Dec;34(3):423-8.
2
The role of Fc and C3b receptors in phagocytosis by inflammatory polymorphonuclear leucocytes in man.Fc和C3b受体在人类炎症性多形核白细胞吞噬作用中的作用。
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3
IgA-mediated inhibition of human leucocyte function by interference with Fc gamma and C3b receptors.通过干扰Fcγ和C3b受体，IgA介导对人白细胞功能的抑制。
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本文引用的文献

1
Assessment of phagocytic and antimicrobial activity of human granulocytes.评估人类粒细胞的吞噬和抗菌活性。
Infect Immun. 1974 Nov;10(5):1120-6. doi: 10.1128/iai.10.5.1120-1126.1974.
2
CHARACTERISTICS OF AN IMMUNE SYSTEM COMMON TO CERTAIN EXTERNAL SECRETIONS.某些外分泌液共有的免疫系统特征。
J Exp Med. 1965 Jan 1;121(1):101-24. doi: 10.1084/jem.121.1.101.
3
Chromatography of serum proteins in normal and pathologic sera: the distribution of protein-bound carbohydrate and cholesterol, siderophilin, thyroxin-binding protein, B12-binding protein, alkaline and acid phosphatases, radio-iodinated albumin and myeloma proteins.正常血清和病理血清中血清蛋白的色谱分析：蛋白结合碳水化合物和胆固醇、转铁蛋白、甲状腺素结合蛋白、维生素B12结合蛋白、碱性和酸性磷酸酶、放射性碘化白蛋白及骨髓瘤蛋白的分布
J Clin Invest. 1958 Feb;37(2):272-84. doi: 10.1172/JCI103606.
4
The isolation and biologic activities of purified secretory IgA and IgG anti-Salmonella typhimurium "O" antibodies from rabbit intestinal fluid and colostrum.从兔肠道液和初乳中分离纯化分泌型IgA及抗鼠伤寒沙门氏菌“O”抗体IgG并研究其生物学活性
J Immunol. 1971 Jan;106(1):181-90.
5
Chemotaxis of polymorphonuclear leukocytes from patients with rheumatoid arthritis.类风湿性关节炎患者多形核白细胞的趋化性。
J Clin Invest. 1971 Dec;50(12):2541-9. doi: 10.1172/JCI106754.
6
Phagocytic function of polymorphonuclear leukocytes in rheumatic diseases.风湿性疾病中多形核白细胞的吞噬功能
J Clin Invest. 1973 Jul;52(7):1632-5. doi: 10.1172/JCI107342.
7
Cytophilic properties of IgA to human neutrophils.免疫球蛋白A对人中性粒细胞的亲细胞特性。
Adv Exp Med Biol. 1974;45(0):67-74. doi: 10.1007/978-1-4613-4550-3_8.
8
Blocking serum lysis of Brucella abortus by hyperimmune rabbit immunoglubulin A.用超免疫兔免疫球蛋白A阻断流产布鲁氏菌的血清溶解作用。
J Immunol. 1971 Jul;107(1):41-6.
9
Purification of human IgA by salt-mediated hydrophobic chromatography.通过盐介导的疏水色谱法纯化人免疫球蛋白A
Immunochemistry. 1976 Feb;13(2):135-9. doi: 10.1016/0019-2791(76)90281-0.
10
The role of leukocytes and their hydrolases in the persistence, degradation, and transport of bacterial constituents in tissues: relation to chronic inflammatory processes in staphylococcal, streptococcal, and mycobacterial infections and in chronic periodontal disease.白细胞及其水解酶在组织中细菌成分的存留、降解和转运中的作用：与葡萄球菌、链球菌和分枝杆菌感染以及慢性牙周病中的慢性炎症过程的关系。
CRC Crit Rev Microbiol. 1976 Mar;4(3):249-322. doi: 10.3109/10408417609106944.

IgA对人多形核白细胞介导的IgG吞噬作用的抑制

Suppression by IgA of IgG-mediated phagocytosis by human polymorphonuclear leucocytes.

作者信息

Wilton J M

出版信息

Clin Exp Immunol. 1978 Dec;34(3):423-8.

PMID:369752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537540/
Abstract

IgA from normal human serum, a myeloma IgA and human colostral IgA were found to inhibit the IgG-dependent phagocytosis of (CA) blastospores by polymorphonuclear leucocytes (PMN) from normal human subjects. The inhibition was dependent on the Fc portion of IgA, was enhanced by heat treatment (56°C for 20 min) and depended on binding to the PMN, but not to the opsonized particle. Binding of CA to the PMN IgG Fc receptor was inhibited, whilst the binding to the PMN C3b receptor was unaffected.

摘要

已发现来自正常人血清的IgA、一种骨髓瘤IgA和人初乳IgA可抑制正常人多形核白细胞（PMN）对（CA）芽生孢子的IgG依赖性吞噬作用。这种抑制作用取决于IgA的Fc部分，经热处理（56℃ 20分钟）后增强，且取决于与PMN的结合，但不取决于与调理素化颗粒的结合。CA与PMN IgG Fc受体的结合受到抑制，而与PMN C3b受体的结合未受影响。