Wang Junjie, Yuan Bo, Yin Ruixue, Zhang Hongbo
School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai 200237, China.
Spine Center, Department of Orthopaedics, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China.
J Funct Biomater. 2023 Mar 21;14(3):169. doi: 10.3390/jfb14030169.
Physical stimuli play an important role in one tissue engineering. Mechanical stimuli, such as ultrasound with cyclic loading, are widely used to promote bone osteogenesis; however, the inflammatory response under physical stimuli has not been well studied. In this paper, the signaling pathways related to inflammatory responses in bone tissue engineering are evaluated, and the application of physical stimulation to promote osteogenesis and its related mechanisms are reviewed in detail; in particular, how physical stimulation alleviates inflammatory responses during transplantation when employing a bone scaffolding strategy is discussed. It is concluded that physical stimulation (e.g., ultrasound and cyclic stress) helps to promote osteogenesis while reducing the inflammatory response. In addition, apart from 2D cell culture, more consideration should be given to the mechanical stimuli applied to 3D scaffolds and the effects of different force moduli while evaluating inflammatory responses. This will facilitate the application of physiotherapy in bone tissue engineering.
物理刺激在组织工程中发挥着重要作用。机械刺激，如具有循环负荷的超声，被广泛用于促进骨生成；然而，物理刺激下的炎症反应尚未得到充分研究。本文评估了骨组织工程中与炎症反应相关的信号通路，并详细综述了物理刺激促进骨生成的应用及其相关机制；特别讨论了在采用骨支架策略进行移植时，物理刺激如何减轻炎症反应。得出的结论是，物理刺激（如超声和循环应力）有助于促进骨生成，同时减少炎症反应。此外，除了二维细胞培养外，在评估炎症反应时，应更多地考虑施加于三维支架的机械刺激以及不同力模量的影响。这将有助于物理治疗在骨组织工程中的应用。
