Kumar S, Mansel R E, Wilson D W, Read G F, Truran P L, Hughes L E, Griffiths K
Br J Surg. 1986 Apr;73(4):260-3. doi: 10.1002/bjs.1800730406.
Progesterone levels were measured in samples of saliva collected daily throughout the menstrual cycle in patients with pronounced cyclical mastalgia and breast nodularity. A control group matched for age, length of menstrual cycle and parity was also studied. No significant differences in progesterone levels were detected between the two groups for the luteal phase of the cycle. These data indicate that cyclical mastalgia is not associated with significant luteal phase progesterone insufficiency, as demonstrated by salivary levels and, by implication, serum levels of progesterone.
在整个月经周期中，每天收集有明显周期性乳房疼痛和乳腺结节的患者的唾液样本，测量其中的孕酮水平。还研究了一个在年龄、月经周期长度和产次方面相匹配的对照组。在月经周期的黄体期，两组之间未检测到孕酮水平有显著差异。这些数据表明，周期性乳房疼痛与黄体期孕酮显著不足无关，唾液中孕酮水平以及由此推断的血清中孕酮水平都证明了这一点。
