Read G F, Bradley J A, Wilson D W, George W D, Griffiths K
Eur J Cancer Clin Oncol. 1985 Jan;21(1):9-17. doi: 10.1016/0277-5379(85)90194-4.
Salivary progesterone concentrations were determined in premenopausal parous women with a mean age of ca. 40 yr who had a history of either benign breast disease (n = 15) or primary breast cancer (n = 15) and in a group of age-matched healthy women (n = 15). Saliva samples were collected at 09.00 and 21.00 hr daily for one complete menstrual cycle and progesterone concentration was measured by radioimmunoassay. Characteristic luteal-phase progesterone profiles were observed in all subjects in each of the three groups but no statistical intergroup differences could be demonstrated for age-matched subjects in each group. These studies indicated that ovarian dysfunction, as judged from salivary progesterone concentrations, was not apparent in older premenopausal women with a history of benign breast disease or primary breast cancer when compared with age-matched controls.
对平均年龄约40岁、有良性乳腺疾病史（n = 15）或原发性乳腺癌史（n = 15）的绝经前经产妇以及一组年龄匹配的健康女性（n = 15）测定唾液孕酮浓度。在一个完整的月经周期内，每天09:00和21:00采集唾液样本，并用放射免疫分析法测定孕酮浓度。三组中的所有受试者均观察到典型的黄体期孕酮曲线，但每组年龄匹配的受试者之间未显示出统计学上的组间差异。这些研究表明，从唾液孕酮浓度判断，与年龄匹配的对照组相比，有良性乳腺疾病或原发性乳腺癌史的老年绝经前女性未出现明显的卵巢功能障碍。
