Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
Department of Pediatrics, University of Wisconsin-Madison; Madison, Wisconsin, Unites States of America.
PLoS Pathog. 2023 Mar 28;19(3):e1011282. doi: 10.1371/journal.ppat.1011282. eCollection 2023 Mar.
In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about the impacts of gestational African-lineage ZIKV infections. Given high human immunodeficiency virus (HIV) burdens in regions where African-lineage ZIKV circulates, we evaluated whether pregnant rhesus macaques infected with simian immunodeficiency virus (SIV) have a higher risk of African-lineage ZIKV-associated birth defects. Remarkably, in both SIV+ and SIV- animals, ZIKV infection early in the first trimester caused a high incidence (78%) of spontaneous pregnancy loss within 20 days. These findings suggest a significant risk for early pregnancy loss associated with African-lineage ZIKV infection and provide the first consistent ZIKV-associated phenotype in macaques for testing medical countermeasures.
在 2016 年寨卡病毒（ZIKV）大流行期间，在母亲怀孕期间感染亚洲谱系 ZIKV 的婴儿中出现了以前未被认识到的出生缺陷风险。关于妊娠期感染非洲谱系 ZIKV 的影响知之甚少。鉴于在非洲谱系 ZIKV 流行的地区人类免疫缺陷病毒（HIV）负担很高，我们评估了感染猴免疫缺陷病毒（SIV）的妊娠恒河猴是否具有更高的感染非洲谱系 ZIKV 相关出生缺陷的风险。值得注意的是，在 SIV+ 和 SIV-动物中，ZIKV 在妊娠早期第一 trimester 的感染在 20 天内导致了高比例（78%）的自发性妊娠丢失。这些发现表明，非洲谱系 ZIKV 感染与早期妊娠丢失相关的风险显著增加，并为检测医学应对措施提供了恒河猴中与 ZIKV 相关的首个一致表型。
