在新冠疫情期间，印度一些较新的邦发现了寨卡这种媒介传播疾病。
Zika a Vector Borne Disease Detected in Newer States of India Amidst the COVID-19 Pandemic.
作者信息
Yadav Pragya D, Kaur Harmanmeet, Gupta Nivedita, Sahay Rima R, Sapkal Gajanan N, Shete Anita M, Deshpande Gururaj R, Mohandas Sreelekshmy, Majumdar Triparna, Patil Savita, Pandit Priyanka, Kumar Abhinendra, Nyayanit Dimpal A, Sreelatha K H, Manjusree S, Sami Hiba, Khan Haris Mazoor, Malhotra Anuradha, Dhingra Kanwardeep, Gadepalli Ravisekhar, Sudha Rani V, Singh Manoj Kumar, Joshi Yash, Dudhmal Manisha, Duggal Nandini, Chabbra Mala, Dar Lalit, Gawande Pranita, Yemul Jyoti, Kalele Kaumudi, Arjun Rajalakshmi, Nagamani K, Borkakoty Biswa, Sahoo Ganesh, Praharaj Ira, Dutta Shanta, Barde Pradip, Jaryal S C, Rawat Vinita
机构信息
Indian Council of Medical Research, National Institute of Virology, Pune, India.
Indian Council of Medical Research, V. Ramalingaswami Bhawan, New Delhi, India.
出版信息
Front Microbiol. 2022 Jun 10;13:888195. doi: 10.3389/fmicb.2022.888195. eCollection 2022.
BACKGROUND
During the second wave of the COVID-19 pandemic, outbreaks of Zika were reported from Kerala, Uttar Pradesh, and Maharashtra, India in 2021. The Dengue and Chikungunya negative samples were retrospectively screened to determine the presence of the Zika virus from different geographical regions of India.
METHODS
During May to October 2021, the clinical samples of 1475 patients, across 13 states and a union territory of India were screened and re-tested for Dengue, Chikungunya and Zika by CDC Trioplex Real time RT-PCR. The Zika rRTPCR positive samples were further screened with anti-Zika IgM and Plaque Reduction Neutralization Test. Next generation sequencing was used for further molecular characterization.
RESULTS
The positivity was observed for Zika (67), Dengue (121), and Chikungunya (10) amongst screened cases. The co-infections of Dengue/Chikungunya, Dengue/Zika, and Dengue/Chikungunya/Zika were also observed. All Zika cases were symptomatic with fever (84%) and rash (78%) as major presenting symptoms. Of them, four patients had respiratory distress, one presented with seizures, and one with suspected microcephaly at birth. The Asian Lineage of Zika and all four serotypes of Dengue were found in circulation.
CONCLUSION
Our study indicates the spread of the Zika virus to several states of India and an urgent need to strengthen its surveillance.
背景
在2019冠状病毒病大流行的第二波期间，2021年印度喀拉拉邦、北方邦和马哈拉施特拉邦报告了寨卡疫情。对登革热和基孔肯雅热阴性样本进行回顾性筛查，以确定印度不同地理区域寨卡病毒的存在情况。
方法
2021年5月至10月，对印度13个邦和1个联邦属地的1475例患者的临床样本进行筛查，并通过美国疾病控制与预防中心（CDC）三重实时逆转录聚合酶链反应（RT-PCR）对登革热、基孔肯雅热和寨卡进行重新检测。寨卡逆转录实时聚合酶链反应（rRTPCR）阳性样本进一步用抗寨卡免疫球蛋白M（IgM）和空斑减少中和试验进行筛查。采用下一代测序进行进一步的分子特征分析。
结果
在筛查病例中，寨卡（67例）、登革热（121例）和基孔肯雅热（10例）呈阳性。还观察到登革热/基孔肯雅热、登革热/寨卡和登革热/基孔肯雅热/寨卡的合并感染情况。所有寨卡病例均有症状，主要症状为发热（84%）和皮疹（78%）。其中，4例患者有呼吸窘迫，1例出现癫痫发作，1例出生时疑似小头畸形。发现寨卡病毒的亚洲谱系和所有四种血清型的登革热病毒在传播。
结论
我们的研究表明寨卡病毒已传播到印度的多个邦，迫切需要加强其监测。
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