Department of Life Sciences, College of Natural Sciences, Ewha Womans University, Seoul 03760, Korea.
BMB Rep. 2023 Apr;56(4):209-215. doi: 10.5483/BMBRep.2023-0021.
Maintaining internal homeostasis and regulating innate behaviors are essential for animal survival. In various animal species, a highly conserved neuroendocrine system integrates sensory inputs and regulates physiological responses to environmental and internal changes. Diuretic hormones 44 and 31, which are homologs of mammalian corticotropin-releasing factor (CRF) and calcitonin gene-related peptide (CGRP), respectively, control body fluid secretion in Drosophila. These neuropeptides and their receptors have multiple physiological roles, including the regulation of body-fluid secretion, sleep:wake cycle, internal nutrientsensing, and CO-dependent response. This review discusses the physiological and behavioral roles of DH44 and DH31 signaling pathways, consisting of neuroendocrine cells that secrete DH44 or DH31 peptides and their receptor-expressing organs. Further research is needed to understand the regulatory mechanisms of the behavioral processes mediated by these neuroendocrine systems. [BMB Reports 2023; 56(4): 209-215].
维持内部平衡和调节先天行为对于动物的生存至关重要。在各种动物物种中，高度保守的神经内分泌系统整合了感觉输入，并调节对环境和内部变化的生理反应。利尿激素 44 和 31 分别是哺乳动物促肾上腺皮质激素释放因子 (CRF) 和降钙素基因相关肽 (CGRP) 的同源物，它们控制果蝇的体液分泌。这些神经肽及其受体具有多种生理作用，包括调节体液分泌、睡眠-觉醒周期、内部营养感应和 CO 依赖性反应。本文综述了由分泌 DH44 或 DH31 肽的神经内分泌细胞及其受体表达器官组成的 DH44 和 DH31 信号通路的生理和行为作用。需要进一步研究来了解这些神经内分泌系统介导的行为过程的调节机制。[BMB 报告 2023;56(4):209-215]。
