来自形成蘑菇的真菌的生物活性化合物
Bioactive Compounds from the Mushroom-Forming Fungus .
作者信息
Wu Jing, Ohura Takeru, Ogura Ryuhei, Wang Junhong, Choi Jae-Hoon, Kobori Hajime, D'Alessandro-Gabazza Corina N, Toda Masaaki, Yasuma Taro, Gabazza Esteban C, Takikawa Yuichi, Hirai Hirofumi, Kawagishi Hirokazu
机构信息
Faculty of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan.
Research Institute for Mushroom Science, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan.
出版信息
Antibiotics (Basel). 2023 Mar 16;12(3):596. doi: 10.3390/antibiotics12030596.
A novel compound () along with two known compounds ( and ) were isolated from the culture broth of , and three known compounds (-) were isolated from its fruiting bodies. The planar structure of was determined by the interpretation of spectroscopic data. By comparing the specific rotation of the compound with that of the analog compound, the absolute configuration of was determined to be . This is the first time that compounds - were isolated from a mushroom-forming fungus. Compound showed significant inhibition activity against Axl and immune checkpoints (PD-L1, PD-L2). In the bioassay to examine growth inhibitory activity against the phytopathogenic bacteria , and , compounds and inhibited the growth of and In the bioassay to examine plant growth regulatory activity, compounds - showed a significant regulatory activity on lettuce growth.
从[具体真菌名称]的培养液中分离出一种新型化合物（）以及两种已知化合物（和），并从其子实体中分离出三种已知化合物（-）。通过光谱数据解析确定了的平面结构。通过将该化合物的比旋光度与类似化合物的比旋光度进行比较，确定的绝对构型为。这是首次从形成蘑菇的真菌中分离出化合物-。化合物对Axl和免疫检查点（PD-L1、PD-L2）表现出显著的抑制活性。在检测对植物病原菌、和生长抑制活性的生物测定中，化合物和抑制了和的生长。在检测植物生长调节活性的生物测定中，化合物-对生菜生长表现出显著的调节活性。
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