Lu Shuya, Cui Qingfa, Zheng Huan, Ma Yuan, Kang Yanchun, Tang Ke
Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Cell Architecture Research Center, Huazhong University of Science and Technology, Wuhan 430030, China.
Bioengineering (Basel). 2023 Mar 3;10(3):325. doi: 10.3390/bioengineering10030325.
Extracellular vesicles (EVs) are membrane-bound vesicles that can be released by all cell types. They may have different biogenesis, physical features, and cargo. EVs are important biomarkers for the diagnosis and prediction of many diseases due to their essential role in intercellular communication, their highly variable cargoes, and their accumulation in various body fluids. These natural particles have been investigated as potential therapeutic materials for many diseases. In our previous studies, the clinical usage of tumor-cell-derived microparticles (T-MPs) as a novel medication delivery system was examined. This review summarizes the clinical translation of EVs and related clinical trials, aiming to provide suggestions for safer and more effective oncology therapeutic systems, particularly in biotherapeutic and immunotherapeutic systems.
细胞外囊泡（EVs）是可由所有细胞类型释放的膜结合囊泡。它们可能具有不同的生物发生、物理特征和货物。由于EVs在细胞间通讯中的重要作用、其高度可变的货物以及它们在各种体液中的积累，它们是许多疾病诊断和预测的重要生物标志物。这些天然颗粒已被研究作为许多疾病的潜在治疗材料。在我们之前的研究中，研究了肿瘤细胞衍生的微粒（T-MPs）作为一种新型药物递送系统的临床应用。本综述总结了EVs的临床转化及相关临床试验，旨在为更安全、更有效的肿瘤治疗系统提供建议，特别是在生物治疗和免疫治疗系统中。
