孕期暴露于酒精的小鼠后代心脏和海马肾素-血管紧张素及激肽释放酶-激肽系统表达中的性别二态性
Sexual Dimorphism in the Expression of Cardiac and Hippocampal Renin-Angiotensin and Kallikrein-Kinin Systems in Offspring from Mice Exposed to Alcohol during Gestation.
作者信息
da Silva Gabriel Almeida, Atum Allan Luís Barboza, de Matos Leonardo Paroche, Nasuk Guilherme Rabelo, de Jesus Bruna Calixto, Gouveia Telma Luciana Furtado, Baltatu Ovidiu Constantin, Zamuner Stella Regina, Silva Júnior José Antônio
机构信息
Medicine Department, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 249, Liberdade, São Paulo 01504-001, SP, Brazil.
Odontology Department, Ágora Faculty, Av. Sorrento, Campo Novo do Parecis 78360-000, MT, Brazil.
出版信息
Antioxidants (Basel). 2023 Feb 21;12(3):541. doi: 10.3390/antiox12030541.
Prenatal alcohol exposure (PAE) impairs fetal development. Alcohol consumption was shown to modulate the renin-angiotensin system (RAS). This study aimed to analyze the effects of PAE on the expression of the renin-angiotensin system (RAS) and kallikrein-kinin system (KKS) peptide systems in the hippocampus and heart of mice of both sexes. C57Bl/6 mice were exposed to alcohol during pregnancy at a concentration of 10% (/). On postnatal day 45 (PN45), mouse hippocampi and left ventricles (LV) were collected and processed for messenger RNA (mRNA) expression of components of the RAS and KKS. In PAE animals, more pronounced expression of and in males and a restored expression in females were observed in both tissues. In LV, increased , , and expressions were also observed in PAE females. Furthermore, high levels of HO were observed in males from the PAE group in both tissues. Taken together, our results suggest that modulation of the expression of these peptidergic systems in PAE females may make them less susceptible to the effects of alcohol.
产前酒精暴露（PAE）会损害胎儿发育。研究表明，饮酒会调节肾素-血管紧张素系统（RAS）。本研究旨在分析PAE对雌雄小鼠海马体和心脏中肾素-血管紧张素系统（RAS）和激肽释放酶-激肽系统（KKS）肽系统表达的影响。C57Bl/6小鼠在孕期暴露于浓度为10%（/）的酒精环境中。在出生后第45天（PN45），收集小鼠的海马体和左心室（LV），并对RAS和KKS各组分的信使核糖核酸（mRNA）表达进行分析。在PAE动物中，在两种组织中均观察到雄性小鼠中 和 的表达更为明显，而雌性小鼠中 的表达得以恢复。在LV中，PAE雌性小鼠中 、 和 的表达也有所增加。此外，在PAE组的雄性小鼠的两种组织中均观察到高水平的HO。综上所述，我们的结果表明，PAE雌性小鼠中这些肽能系统表达的调节可能使它们对酒精的影响更不易感。
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