Ikawa E, Tsuda H, Sakata T, Masui T, Satoh K, Sato K, Ito N
Cancer Lett. 1986 Apr;31(1):53-60. doi: 10.1016/0304-3835(86)90166-7.
The modification potentials of ethyl alcohol (EA) and acetaldehyde (AA) on development of immunohistochemical glutathione S-transferase (placental type)-positive (GST-P+) liver cell foci were examined in an in vivo short-term assay system. Rats were given a single intraperitoneal injection of diethylnitrosamine (DEN) and then various concentrations of EA (20, 10, 5%) or AA (5, 2.5%) in their drinking water from week 2 till termination in week 6. All rats were subjected to two-thirds partial hepatectomy in week 3. Animals given EA (20% and 10%) or AA showed significant decrease in liver and body weight. However, only EA caused significant dose-related inhibition of development of areas of foci (mm2/cm2), but AA had no effect on their development.
在一个体内短期检测系统中，研究了乙醇（EA）和乙醛（AA）对免疫组化谷胱甘肽S-转移酶（胎盘型）阳性（GST-P+）肝细胞灶发展的修饰潜力。给大鼠腹腔注射一次二乙基亚硝胺（DEN），然后从第2周直到第6周处死，在它们的饮用水中加入不同浓度的EA（20%、10%、5%）或AA（5%、2.5%）。所有大鼠在第3周接受了三分之二部分肝切除术。给予EA（20%和10%）或AA的动物肝脏和体重显著下降。然而，只有EA引起了灶面积（mm2/cm2）发展的显著剂量相关抑制，而AA对其发展没有影响。
