肠道微生物群、成人隐匿性自身免疫性糖尿病与1型糖尿病：一种不断演变的关系

Piccioni Andrea, Rosa Federico, Mannucci Sergio, Manca Federica, Merra Giuseppe, Chiloiro Sabrina, Candelli Marcello, Covino Marcello, Gasbarrini Antonio, Franceschi Francesco

Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Facoltà di Medicina e Chirurgia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

Biomedicines. 2023 Feb 25;11(3):707. doi: 10.3390/biomedicines11030707.

There is much evidence confirming the crucial role played by the gut microbiota in modulating the immune system in the onset of autoimmune diseases. In this article, we focus on the relationship between alterations in the microbiome and the onset of diabetes mellitus type 1 and LADA, in light of the latest evidence. We will then look at both how the role of the gut microbiota appears to be increasingly crucial in the pathogenesis of these disorders and how this aspect may be instrumental in the development of new potential therapeutic strategies that modulate the gut microbiota, such as probiotics, prebiotics, and fecal microbiota transplantation.

有大量证据证实肠道微生物群在自身免疫性疾病发病过程中调节免疫系统所起的关键作用。在本文中，根据最新证据，我们聚焦于微生物组改变与1型糖尿病和成人隐匿性自身免疫性糖尿病发病之间的关系。然后，我们将探讨肠道微生物群的作用在这些疾病的发病机制中如何显得越来越关键，以及这一方面如何有助于开发调节肠道微生物群的新潜在治疗策略，如益生菌、益生元及粪便微生物群移植。