Pisano Massimo, Romano Antonio, Di Palo Maria Pia, Baroni Adone, Serpico Rosario, Contaldo Maria
Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy.
Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Biomedicines. 2023 Mar 10;11(3):846. doi: 10.3390/biomedicines11030846.
Oral Candidiasis (OC) is an opportunistic fungal infection of the oral cavity, frequently reported under local and systemic predisposing circumstances. While the recurrence of OC HIV-infected subjects has been well described and reported, the association between oral candidiasis and the SARS-CoV-2 infection is a recent finding that still is worthy of further study. The present paper focuses on this novel association, reporting the incidence and prevalence of OC occurring during and after COVID-19 and the possible etiopathogenic mechanisms underlying the onset of OC in COVID-19 subjects. The work found that the immune inflammatory hypo reactions and immunosuppression found in children and adults with COVID-19 could favor the proliferation colonization of species and the following infection. At the same time, poor oral hygiene and iatrogenic causes seem to be the main risk factors.
口腔念珠菌病(OC)是口腔的一种机会性真菌感染,在局部和全身易感情况下经常有报告。虽然OC在HIV感染患者中的复发情况已有充分描述和报道,但口腔念珠菌病与新型冠状病毒2(SARS-CoV-2)感染之间的关联是一项新发现,仍值得进一步研究。本文聚焦于这一新的关联,报告了COVID-19期间及之后发生的OC的发病率和患病率,以及COVID-19患者中OC发病的可能病因机制。研究发现,COVID-19儿童和成人中出现的免疫炎症低反应和免疫抑制可能有利于念珠菌属物种的增殖定植及随后的感染。同时,口腔卫生不良和医源性因素似乎是主要危险因素。