Teanpaisan R, Nittayananta W
Department of Stomatology, Faculty of Dentistry, Prince of Songkla University, Thailand.
J Oral Pathol Med. 1998 Jan;27(1):4-7. doi: 10.1111/j.1600-0714.1998.tb02082.x.
The purpose of this study was to examine the prevalence of Candida species among groups of HIV-infected and HIV-free subjects in Thailand and to ascertain whether particular Candida species were associated with HIV infection. Oral rinse specimens were collected from 45 AIDS patients (CDC stage IV), 74 HIV-free healthy subjects, and 42 HIV-free patients who had clinical candidiasis. Yeasts recovered in culture were identified and quantified. The mean ages of the cohorts were 30.75+/-8.19 years (AIDS group), 28.50+/-7.98 (HIV-free healthy group) and 41.83+/-12.25 years (HIV-free candidiasis group). Yeasts were isolated from 30/45 (66.66%, range 6.6x10(2)-5.7x10(6) CFU/ml) of the AIDS group, 8/74 (10.81%, range 8.0x10(1)-3.5x10(4) CFU/ml) of the HIV-free healthy group, and 24/42 (57.14%, range 1.0x10(2)-1.1x10(5) CFU/ml) of the HIV-free candidiasis group. There were statistically significant differences in the Candida colony counts between the AIDS group without oral candidiasis and the healthy group (P=0.0078) and between the AIDS group with candidiasis and the HIV-free, oral candidiasis group (P=0.0003). Candida albicans was the most common species recovered from AIDS patients (29 out of 30; 96.66%).
本研究的目的是调查泰国感染HIV和未感染HIV人群中念珠菌属的流行情况，并确定特定的念珠菌属是否与HIV感染有关。从45名艾滋病患者（美国疾病控制与预防中心IV期）、74名未感染HIV的健康受试者以及42名患有临床念珠菌病的未感染HIV患者中收集口腔冲洗标本。对培养中分离出的酵母菌进行鉴定和定量。各队列的平均年龄分别为30.75±8.19岁（艾滋病组）、28.50±7.98岁（未感染HIV的健康组）和41.83±12.25岁（未感染HIV的念珠菌病组）。从30/45名（66.66%，范围为6.6×10²-5.7×10⁶CFU/ml）艾滋病组患者、8/74名（10.81%，范围为8.0×10¹-3.5×10⁴CFU/ml）未感染HIV的健康组受试者以及24/42名（57.14%，范围为1.0×10²-1.1×10⁵CFU/ml）未感染HIV的念珠菌病组患者中分离出酵母菌。在没有口腔念珠菌病的艾滋病组与健康组之间（P=0.0078）以及患有念珠菌病的艾滋病组与未感染HIV的口腔念珠菌病组之间（P=0.0003），念珠菌菌落计数存在统计学显著差异。白色念珠菌是从艾滋病患者中分离出的最常见菌种（30例中有29例；96.66%）。
