Glavina Ana, Božić Ivona, Parat Katica, Perković Dijana, Biočina-Lukenda Dolores, Martinović Kaliterna Dušanka, Radić Mislav
Dental Clinic Split, 21000 Split, Croatia.
Department of Oral Medicine and Periodontology, Study of Dental Medicine, School of Medicine, University of Split, 21000 Split, Croatia.
Diagnostics (Basel). 2023 Mar 10;13(6):1057. doi: 10.3390/diagnostics13061057.
Determination of salivary flow rate and oral status in patients with primary Sjögren's Syndrome (pSS) and diffuse cutaneous systemic sclerosis (dcSSc) and comparison with control subjects. Thirty-one pSS patients, 28 dcSSc patients, and 28 control subjects participated in this single-center, cross-sectional study. Unstimulated whole salivary flow rate (UWSFR) and stimulated whole salivary flow rate (SWSFR), salivary pH, DMFT index (D-decayed, M-missing, F-filled tooth), periodontal pocket depth (PPD), clinical attachment level (CAL), interincisal distance, and OHRQoL (oral health-related quality of life) were analyzed in all three groups of subjects. Primary SS and dcSSc patients had statistically significant lower values of UWSFR (0.20; 0.38 vs. 0.91 mL/min) and SWSFR (0.56; 0.70 vs. 1.64 mL/min) compared with control subjects ( < 0.001, Kruskal-Wallis test). Salivary pH values were statistically significantly lower in pSS and dcSSc patients compared with control subjects (6.00; 6.25 vs. 7.00, respectively) ( < 0.001, Kruskal-Wallis test). The DMFT index of dcSSc patients was higher (28.50) and statistically significant compared to control subjects (20.00) ( = 0.01). The prevalence of periodontitis was the same in pSS and dcSSc patients and control subjects ( = 0.384). Primary SS and dcSSc patients had a statistically significant decreased interincisal distance compared to control subjects (43.80; 38.00 vs. 48.00) ( = 0.003 and < 0.001, respectively). Primary SS and dcSSc patients show decreased UWSFR and SWSFR, salivary pH values closer to an acidic medium, higher DMFT index, higher prevalence of periodontitis, decreased interincisal distance, and poorer OHRQoL, i.e., poor oral and periodontal health.
原发性干燥综合征（pSS）和弥漫性皮肤系统性硬化症（dcSSc）患者唾液流速及口腔状况的测定及其与对照受试者的比较。31例pSS患者、28例dcSSc患者和28例对照受试者参与了这项单中心横断面研究。分析了所有三组受试者的非刺激性全唾液流速（UWSFR）、刺激性全唾液流速（SWSFR）、唾液pH值、DMFT指数（D-龋坏、M-缺失、F-充填牙）、牙周袋深度（PPD）、临床附着水平（CAL）、切牙间距离和口腔健康相关生活质量（OHRQoL）。与对照受试者相比，原发性干燥综合征和dcSSc患者的UWSFR（0.20；0.38对0.91 mL/分钟）和SWSFR（0.56；0.70对1.64 mL/分钟）值在统计学上显著降低（<0.001，Kruskal-Wallis检验）。与对照受试者相比，pSS和dcSSc患者的唾液pH值在统计学上显著降低（分别为6.00；6.25对7.00）（<0.001，Kruskal-Wallis检验）。dcSSc患者的DMFT指数较高（28.50），与对照受试者（20.00）相比有统计学显著性差异（=0.01）。pSS和dcSSc患者及对照受试者的牙周炎患病率相同（=0.384）。与对照受试者相比，原发性干燥综合征和dcSSc患者的切牙间距离在统计学上显著减小（43.80；38.00对48.00）（分别为=0.003和<0.001）。原发性干燥综合征和dcSSc患者表现出UWSFR和SWSFR降低、唾液pH值更接近酸性介质、DMFT指数更高、牙周炎患病率更高、切牙间距离减小以及OHRQoL较差，即口腔和牙周健康状况不佳。
