加拿大系统性硬化症口腔健康研究：与普通人群相比，系统性硬化症的口腔表现和口腔健康相关生活质量。
The Canadian systemic sclerosis oral health study: orofacial manifestations and oral health-related quality of life in systemic sclerosis compared with the general population.
机构信息
Division of Rheumatology, Department of Internal Medicine, SMBD Jewish General Hospital, Division of Rheumatology, Faculty of Medicine, McGill University, Epidemiology, Lady Davis Institute, SMBD Jewish General Hospital, Department of Mathematics and Statistics, McGill University, Montreal, Quebec, School of Dentistry, University of Western Ontario, Division of Rheumatology, Department of Medicine, University of Western Ontario, London, Ontario, Department of Rheumatology, Université de Sherbrooke, Sherbrooke, Quebec, Department of Periodontology, Faculty of Dentistry, Division of Rheumatology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Division of Oro-facial Pain, School of Dentistry, Department of Medicine, University of Alberta, Edmonton, Alberta, Department of Pathology, College of Dentistry, University of Saskatchewan, Division of Rheumatology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Department of Periodontology, Rheumatology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba and Department of Dentistry, SMBD Jewish General Hospital, Montreal, Quebec, Canada.Division of Rheumatology, Department of Internal Medicine, SMBD Jewish General Hospital, Division of Rheumatology, Faculty of Medicine, McGill University, Epidemiology, Lady Davis Institute, SMBD Jewish General Hospital, Department of Mathematics and Statistics, McGill University, Montreal, Quebec, School of Dentistry, University of Western Ontario, Division of Rheumatology, Department of Medicine, University of Western Ontario, London, Ontario, Department of Rheumatology, Université de Sherbrooke, Sherbrooke, Quebec, Department of Periodontology, Faculty of Dentistry, Division of Rheumatology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Division of Oro-facial Pain, School of Dentistry, Department of Medicine, University of Alberta, Edmonton, Alberta, Department of Pathology, College of Dentistry, University of Sask
Division of Rheumatology, Department of Internal Medicine, SMBD Jewish General Hospital, Division of Rheumatology, Faculty of Medicine, McGill University, Epidemiology, Lady Davis Institute, SMBD Jewish General Hospital, Department of Mathematics and Statistics, McGill University, Montreal, Quebec, School of Dentistry, University of Western Ontario, Division of Rheumatology, Department of Medicine, University of Western Ontario, London, Ontario, Department of Rheumatology, Université de Sherbrooke, Sherbrooke, Quebec, Department of Periodontology, Faculty of Dentistry, Division of Rheumatology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Division of Oro-facial Pain, School of Dentistry, Department of Medicine, University of Alberta, Edmonton, Alberta, Department of Pathology, College of Dentistry, University of Saskatchewan, Division of Rheumatology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Department of Periodontology, Rheumatology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba and Department of Dentistry, SMBD Jewish General Hospital, Montreal, Quebec, Canada.
出版信息
Rheumatology (Oxford). 2014 Aug;53(8):1386-94. doi: 10.1093/rheumatology/ket441. Epub 2014 Jan 24.
OBJECTIVE
The aim of this study was to compare oral abnormalities and oral health-related quality of life (HRQoL) of patients with SSc with the general population.
METHODS
SSc patients and healthy controls were enrolled in a multisite cross-sectional study. A standardized oral examination was performed. Oral HRQoL was measured with the Oral Health Impact Profile (OHIP). Multivariate regression analyses were performed to identify associations between SSc, oral abnormalities and oral HRQoL.
RESULTS
We assessed 163 SSc patients and 231 controls. SSc patients had more decayed teeth (SSc 0.88, controls 0.59, P = 0.0465) and periodontal disease [number of teeth with pocket depth (PD) >3 mm or clinical attachment level (CAL) ≥5.5 mm; SSc 5.23, controls 2.94, P < 0.0001]. SSc patients produced less saliva (SSc 147.52 mg/min, controls 163.19 mg/min, P = 0.0259) and their interincisal distance was smaller (SSc 37.68 mm, controls 44.30 mm, P < 0.0001). SSc patients had significantly reduced oral HRQoL compared with controls (mean OHIP score: SSc 41.58, controls 26.67, P < 0.0001). Multivariate regression analyses confirmed that SSc was a significant independent predictor of missing teeth, periodontal disease, interincisal distance, saliva production and OHIP scores.
CONCLUSION
Subjects with SSc have impaired oral health and oral HRQoL compared with the general population. These data can be used to develop targeted interventions to improve oral health and HRQoL in SSc.
目的
本研究旨在比较 SSc 患者的口腔异常和口腔健康相关生活质量（HRQoL）与普通人群的差异。
方法
在一项多中心横断面研究中，纳入了 SSc 患者和健康对照者。对所有受试者进行标准化口腔检查。采用 Oral Health Impact Profile（OHIP）量表评估口腔 HRQoL。采用多变量回归分析确定 SSc、口腔异常与口腔 HRQoL 之间的关系。
结果
共评估了 163 例 SSc 患者和 231 名对照者。SSc 患者的龋齿数（SSc 0.88，对照组 0.59，P = 0.0465）和牙周病（探诊深度 >3 mm 或临床附着丧失 >5.5 mm 的牙齿数；SSc 5.23，对照组 2.94，P < 0.0001）更多。SSc 患者的唾液分泌量更少（SSc 147.52 mg/min，对照组 163.19 mg/min，P = 0.0259），切牙间距离更小（SSc 37.68 mm，对照组 44.30 mm，P < 0.0001）。与对照组相比，SSc 患者的口腔 HRQoL 显著降低（平均 OHIP 评分：SSc 41.58，对照组 26.67，P < 0.0001）。多变量回归分析证实，SSc 是牙齿缺失、牙周病、切牙间距离、唾液分泌量和 OHIP 评分的独立预测因素。
结论
与普通人群相比，SSc 患者的口腔健康和口腔 HRQoL 受损。这些数据可用于制定有针对性的干预措施，以改善 SSc 患者的口腔健康和 HRQoL。
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