Pettit B R
Clin Chim Acta. 1986 Apr 15;156(1):85-90. doi: 10.1016/0009-8981(86)90182-8.
A selected ion monitoring assay for thiodiglycollic acid in urine is described. Urine samples are analysed by combined gas chromatography-mass spectrometry as their dibutyl esters using pimelic acid as an internal standard. Rapid analysis was achieved by the simplification of sample preparation. The assay has proved to be reliable, with a detection limit of less than 0.5 mumol/l. The excretion of large amounts of thiodiglycollic acid in premature babies urine has been confirmed, with the greatest excretion occurring from those neonates born with a gestational age of 30 wk or less.
本文描述了一种用于检测尿液中硫代二甘醇酸的选择离子监测分析法。尿液样本以庚二酸作为内标，通过气相色谱-质谱联用仪分析其丁二酸二丁酯。通过简化样品制备实现了快速分析。该分析方法已被证明是可靠的，检测限小于0.5微摩尔/升。已证实在早产儿尿液中会排出大量硫代二甘醇酸，其中胎龄30周及以下的新生儿排出量最大。
