Laboratorio de Neurofisiología, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico.
Departamento de Farmacobiología, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Guadalajara 44430, Mexico.
Molecules. 2022 Jul 15;27(14):4531. doi: 10.3390/molecules27144531.
Ozone (O) is an oxidating tropospheric pollutant. When O interacts with biological substrates, reactive oxygen and nitrogen species (RONS) are formed. Severe oxidative damage exhausts the endogenous antioxidant system, which leads to the decreased activity of antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD). Curcumin (CUR) is a natural polyphenol with well-documented antioxidant and anti-inflammatory properties. The aim of this work is to evaluate the effects of curcumin on CAT, GPx, and SOD activity and the inhibition of oxidative damage after the acute and chronic exposure to O. Fifty male Wistar rats were divided into five experimental groups: the intact control, CUR-fed control, exposed-to-O control, CUR-fed (preventive), and CUR-fed (therapeutic) groups. These two last groups received a CUR-supplemented diet while exposed to O. These experiments were performed during acute- and chronic-exposure phases. In the preventive and therapeutic groups, the activity of plasma CAT, GPx, and SOD was increased during both exposure phases, with slight differences; concomitantly, lipid peroxidation and protein carbonylation were inhibited. For this reason, we propose that CUR could be used to enhance the activity of the antioxidant system and to diminish the oxidative damage caused by exposure to O.
臭氧（O）是一种氧化性的对流层污染物。当 O 与生物基质相互作用时，会形成活性氧和氮物种（RONS）。严重的氧化损伤会耗尽内源性抗氧化系统，导致抗氧化酶如过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）和超氧化物歧化酶（SOD）的活性降低。姜黄素（CUR）是一种具有良好抗氧化和抗炎特性的天然多酚。本工作旨在评估姜黄素对 CAT、GPx 和 SOD 活性的影响，并抑制急性和慢性暴露于 O 后氧化损伤。50 只雄性 Wistar 大鼠分为五组：完整对照组、CUR 喂养对照组、暴露于 O 对照组、CUR 喂养（预防）组和 CUR 喂养（治疗）组。后两组在暴露于 O 的同时接受 CUR 补充饮食。这些实验在急性和慢性暴露阶段进行。在预防和治疗组中，血浆 CAT、GPx 和 SOD 的活性在两个暴露阶段都增加了，略有差异；同时，脂质过氧化和蛋白质羰基化受到抑制。因此，我们提出 CUR 可用于增强抗氧化系统的活性并减少暴露于 O 引起的氧化损伤。
