Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, NO. 2, Min-Sheng Road, Dalin Town, Chiayi County 62247, Taiwan.
Medicina (Kaunas). 2023 Mar 20;59(3):614. doi: 10.3390/medicina59030614.
Patients who require prolonged mechanical ventilation typically experience poor long-term survival outcomes. However, there have been few studies conducted to investigate the five-year survival rate of these patients. This study aims to determine the factors that affect the five-year survival rate of patients who require prolonged mechanical ventilation, with the goal of improving their survival outcomes. The current retrospective, single-center study included all patients who required prolonged mechanical ventilation over a period of six years. We collected data on their age, sex, causes of acute respiratory failure leading to prolonged mechanical ventilation, comorbidities, receipt of a tracheostomy or not, weaning status, discharge conditions, and long-term outcomes. The study examined the long-term outcomes of 403 patients who required prolonged mechanical ventilation until December 2018. Of the study population, 157 patients were successfully weaned from prolonged mechanical ventilation and discharged, 186 patients passed away in the hospital, and 60 patients remained ventilator-dependent. For all 403 patients receiving prolonged mechanical ventilation, the one-year and five-year survival rates were 24.3% and 14.6%, respectively. Among the 243 patients who were successfully weaned from prolonged mechanical ventilation, the corresponding rates were 32.6% and 21.0%. For the 157 discharged prolonged mechanical ventilation patients, the one-year and five-year survival rates were 50.3% and 32.6%, respectively. For the 60 ventilator-dependent patients, the one-year and five-year survival rates were 31.7% and 13.2%, respectively. The study revealed that successfully weaned from invasive mechanical ventilation and the receipt of a tracheostomy were influential factors in the five-year survival rate of patients requiring prolonged mechanical ventilation. Patients requiring prolonged mechanical ventilation may experience poor survival outcomes. Nevertheless, two key factors that can improve their long-term survival are successfully weaned from invasive mechanical ventilation and receipt of a tracheostomy.
需要长时间机械通气的患者通常预后不良。然而，目前很少有研究调查这些患者的五年生存率。本研究旨在确定影响需要长时间机械通气患者五年生存率的因素，以改善其生存结局。
本回顾性单中心研究纳入了六年来所有需要长时间机械通气的患者。我们收集了他们的年龄、性别、导致长时间机械通气的急性呼吸衰竭的原因、合并症、是否接受气管切开术、脱机状态、出院情况和长期结局等数据。
该研究共纳入了 403 名于 2018 年 12 月前接受长时间机械通气的患者，其中 157 名成功脱机并出院，186 名在院死亡，60 名仍依赖呼吸机。所有 403 名接受长时间机械通气的患者，1 年和 5 年生存率分别为 24.3%和 14.6%。在 243 名成功脱机的患者中，相应的生存率分别为 32.6%和 21.0%。在 157 名成功脱机并出院的患者中，1 年和 5 年生存率分别为 50.3%和 32.6%。在 60 名依赖呼吸机的患者中，1 年和 5 年生存率分别为 31.7%和 13.2%。研究表明，成功脱机和接受气管切开术是影响需要长时间机械通气患者 5 年生存率的因素。
需要长时间机械通气的患者可能预后不良。然而，成功脱机和接受气管切开术是改善其长期生存的两个关键因素。
