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不同胃属物种的运动性

Motility of Different Gastric spp.

作者信息

Bansil Rama, Constantino Maira A, Su-Arcaro Clover, Liao Wentian, Shen Zeli, Fox James G

机构信息

Department of Physics, Boston University, Boston, MA 02215, USA.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02138, USA.

出版信息

Microorganisms. 2023 Mar 1;11(3):634. doi: 10.3390/microorganisms11030634.

Abstract

spp., including the well-known human gastric pathogen , can cause gastric diseases in humans and other mammals. They are Gram-negative bacteria that colonize the gastric epithelium and use their multiple flagella to move across the protective gastric mucus layer. The flagella of different spp. vary in their location and number. This review focuses on the swimming characteristics of different species with different flagellar architectures and cell shapes. All spp. use a run-reverse-reorient mechanism to swim in aqueous solutions, as well as in gastric mucin. Comparisons of different strains and mutants of varying in cell shape and the number of flagella show that their swimming speed increases with an increasing number of flagella and is somewhat enhanced with a helical cell body shape. The swimming mechanism of , which has bipolar flagella, is more complex than that of unipolar exhibits multiple modes of flagellar orientation while swimming. The pH-dependent viscosity and gelation of gastric mucin significantly impact the motility of spp. In the absence of urea, these bacteria do not swim in mucin gel at pH < 4, even though their flagellar bundle rotates.

摘要

某些幽门螺杆菌属(spp.),包括著名的人类胃部病原体,可导致人类和其他哺乳动物患上胃部疾病。它们是革兰氏阴性菌,定殖于胃上皮细胞,并利用其多条鞭毛穿过保护性的胃黏液层。不同幽门螺杆菌属的鞭毛在位置和数量上有所不同。本综述聚焦于具有不同鞭毛结构和细胞形状的不同物种的游动特性。所有幽门螺杆菌属在水溶液以及胃黏蛋白中都采用“游动-反向-重新定向”机制游动。对不同菌株以及鞭毛数量和细胞形状各异的幽门螺杆菌突变体的比较表明,它们的游动速度随着鞭毛数量的增加而提高,并且螺旋形细胞体形状会使其游动速度有所增强。具有双极鞭毛的幽门螺杆菌的游动机制比单极幽门螺杆菌更为复杂,在游动时呈现多种鞭毛定向模式。胃黏蛋白的pH依赖性黏度和凝胶化显著影响幽门螺杆菌属的运动性。在没有尿素的情况下,即使它们的鞭毛束旋转,这些细菌在pH < 4的黏蛋白凝胶中也不会游动。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3671/10058440/a2b94ba9b4a2/microorganisms-11-00634-g001.jpg

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