两种海洋海绵来源的 Onnamide 类似物：多烯系统几何效应对生物活性的评价。

Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.

Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.

Molecules. 2023 Mar 9;28(6):2524. doi: 10.3390/molecules28062524.

Two previously unreported onnamide analogs, 2- and 6-onnamides A ( and ), were isolated from the marine sponge collected at Amami-Oshima Is., Kagoshima Prefecture, Japan. Structures of compounds and were elucidated by spectral analysis. Structure-activity relationships (SARs) for effects on histone modifications and cytotoxicity against HeLa and P388 cells were characterized. The geometry in the polyene systems of onnamides affected the histone modification levels and cytotoxicity.

从日本鹿儿岛县奄美大岛采集的海洋海绵中分离得到了两种先前未报道的奥纳米德类似物，即 2- 和 6-奥纳米德 A（和）。通过光谱分析阐明了化合物和的结构。研究了对组蛋白修饰和对 HeLa 和 P388 细胞的细胞毒性的构效关系（SAR）。奥纳米德的多烯系统中的几何形状影响组蛋白修饰水平和细胞毒性。