Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Pharmacy, School of Tropical Medicine, College of Biomedical Information and Engineering, Hainan Medical University, Haikou 571199, China.
School of Pharmacy, North China University of Science and Technology, Tangshan 063210, China.
Molecules. 2023 Mar 16;28(6):2679. doi: 10.3390/molecules28062679.
Polysaccharides from the species of Boletaceae (Boletales, Agaricomycetes, Basidiomycota) are economically significant to both functional foods and medicinal industries. The crude polysaccharide from (BPP) was prepared, and its physicochemical properties were characterized through the use of consecutive experimental apparatus, and its impact on the gut microbiota of Kunming mice was evaluated. Analyses of the structure characteristics revealed that BPP was mainly composed of Man, Glc, and Gal, possessing the pyranose ring and β/α-glycosidic linkages. TG analysis exhibited that BPP had great heat stability. The SEM observation performed demonstrated that BPP appeared with a rough, dense, and porous shape. Through the BPP intervention, the serum and fecal biochemical index in mice can be improved obviously ( < 0.05). The abundance of beneficial microbiota in the BPP-treated group was significantly increased, while the abundance of harmful microbiota was significantly decreased ( < 0.05). Based on the Tax4Fun, we also revealed the relationship between the species of gut microbiota and showed that the high dose of BPP has significantly changed the functional diversities compared with those in other groups ( < 0.05). The results suggest that could serve as potential functional food or medicine.
牛肝菌科（牛肝菌目，伞菌纲，担子菌门）物种的多糖对功能性食品和医药工业都具有重要的经济意义。（BPP）的粗多糖被制备出来，并通过连续的实验设备对其理化性质进行了表征，同时还评估了其对昆明小鼠肠道微生物群的影响。结构特征分析表明，BPP 主要由 Man、Glc 和 Gal 组成，具有吡喃糖环和 β/α-糖苷键。TG 分析表明，BPP 具有很好的热稳定性。SEM 观察表明，BPP 呈现出粗糙、致密和多孔的形状。通过 BPP 干预，可以明显改善小鼠的血清和粪便生化指标（<0.05）。BPP 处理组有益微生物菌群的丰度明显增加，而有害微生物菌群的丰度明显降低（<0.05）。基于 Tax4Fun，我们还揭示了肠道微生物群物种之间的关系，并表明与其他组相比，高剂量的 BPP 显著改变了功能多样性（<0.05）。结果表明，可能作为潜在的功能性食品或药物。
