Sciabica Sabrina, Barbari Riccardo, Fontana Riccardo, Tafuro Giovanni, Semenzato Alessandra, Traini Daniela, Silva Dina M, Reis Larissa Gomes Dos, Canilli Luisa, Terno Massimo, Marconi Peggy, Baldisserotto Anna, Vertuani Silvia, Manfredini Stefano
Department of Life Sciences and Biotechnology, University of Ferrara, via L. Borsari 46, 44121 Ferrara, Italy.
Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, via Fossato di Mortara 64/B, 44121 Ferrara, Italy.
Pharmaceuticals (Basel). 2023 Mar 11;16(3):431. doi: 10.3390/ph16030431.
Hyaluronic acid (HA) is a polymer with unique biological properties that has gained in interest over the years, with applications in pharmaceutical, cosmetic, and biomedical fields; however, its widespread use has been limited by its short half-life. Therefore, a new cross-linked hyaluronic acid was designed and characterized using a natural and safe cross-linking agent, such as arginine methyl ester, which provided improved resistance to enzymatic action, as compared to the corresponding linear polymer. The antibacterial profile of the new derivative was shown to be effective against and , making it a promising candidate for use in cosmetic formulations and skin applications. Its effect on , combined with its excellent tolerability profile on lung cells, also makes this new product suitable for applications involving the respiratory tract.
透明质酸（HA）是一种具有独特生物学特性的聚合物，近年来受到越来越多的关注，在制药、化妆品和生物医学领域都有应用；然而，其广泛应用受到半衰期短的限制。因此，设计了一种新型交联透明质酸，并使用天然安全的交联剂（如精氨酸甲酯）对其进行了表征，与相应的线性聚合物相比，该交联剂提高了对酶作用的抗性。新衍生物的抗菌谱显示对[具体细菌名称1]和[具体细菌名称2]有效，使其成为化妆品配方和皮肤应用中有前景的候选物。它对[具体细胞或生理过程]的作用，再加上其对肺细胞的优异耐受性，也使得这种新产品适用于涉及呼吸道的应用。
