发展中国家儿科患者临时调配制剂的患病率、风险及挑战：一项综述
Prevalence, Risk, and Challenges of Extemporaneous Preparation for Pediatric Patients in Developing Nations: A Review.
作者信息
Yuliani Sri Hartati, Putri Dina Christin Ayuning, Virginia Dita Maria, Gani Michael Raharja, Riswanto Florentinus Dika Octa
机构信息
Division of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sanata Dharma, Yogyakarta 55282, Indonesia.
Division of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Sanata Dharma, Yogyakarta 55282, Indonesia.
出版信息
Pharmaceutics. 2023 Mar 4;15(3):840. doi: 10.3390/pharmaceutics15030840.
Abstract
Extemporaneous preparations are still widely prescribed for pediatric patients with special treatments of certain doses and/or combinations of drugs. Several problems related to extemporaneous preparations have been linked to the incidence of adverse events or a lack of therapeutic effectiveness. Developing nations are facing the challenges of compounding practices. The prevalence of compounded medication in developing nations must be explored to determine the urgency of compounding practices. Furthermore, the risks and challenges are described and explained through investigation and collection of numerous scientific articles from reputable databases, including Web of Science, Scopus, and PubMed. Pediatric patients need compounded medication related to the appropriate dosage form and dosage adjustment. Notably, it is important to observe extemporaneous preparations in order to provide patient-oriented medication.
摘要
临时调配制剂仍被广泛用于接受特定剂量和/或药物组合特殊治疗的儿科患者。与临时调配制剂相关的几个问题已与不良事件的发生率或治疗效果不佳联系在一起。发展中国家正面临着复方制剂操作的挑战。必须探究发展中国家复方药物的流行情况，以确定复方制剂操作的紧迫性。此外，通过从包括科学网、Scopus和PubMed在内的知名数据库中调查和收集大量科学文章，对风险和挑战进行了描述和解释。儿科患者需要与合适剂型和剂量调整相关的复方药物。值得注意的是，观察临时调配制剂对于提供以患者为导向的药物治疗很重要。
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