Czarnecka Kamila, Pilarz Aleksandra, Rogut Aleksandra, Maj Patryk, Szymańska Joanna, Olejnik Łukasz, Szymański Paweł
Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz, Poland.
Department of Radiobiology and Radiation Protection, Military Institute of Hygiene and Epidemiology, 4 Kozielska St., 01-163 Warsaw, Poland.
Nutrients. 2021 Jun 7;13(6):1957. doi: 10.3390/nu13061957.
Aspartame is a sweetener introduced to replace the commonly used sucrose. It was discovered by James M. Schlatter in 1965. Being 180-200 times sweeter than sucrose, its intake was expected to reduce obesity rates in developing countries and help those struggling with diabetes. It is mainly used as a sweetener for soft drinks, confectionery, and medicines. Despite its widespread use, its safety remains controversial. This narrative review investigates the existing literature on the use of aspartame and its possible effects on the human body to refine current knowledge. Taking to account that aspartame is a widely used artificial sweetener, it seems appropriate to continue research on safety. Studies mentioned in this article have produced very interesting results overall, the current review highlights the social problem of providing visible and detailed information about the presence of aspartame in products. The studies involving the impact of aspartame on obesity, diabetes mellitus, children and fetus, autism, neurodegeneration, phenylketonuria, allergies and skin problems, its cancer properties and its genotoxicity were analyzed. Further research should be conducted to ensure clear information about the impact of aspartame on health.
阿斯巴甜是一种为替代常用蔗糖而引入的甜味剂。它于1965年由詹姆斯·M·施拉特发现。由于其甜度比蔗糖高180至200倍，人们预计摄入它能降低发展中国家的肥胖率，并帮助糖尿病患者。它主要用作软饮料、糖果和药品的甜味剂。尽管其使用广泛，但其安全性仍存在争议。这篇叙述性综述调查了关于阿斯巴甜使用及其对人体可能影响的现有文献，以完善当前的认知。考虑到阿斯巴甜是一种广泛使用的人工甜味剂，继续进行安全性研究似乎是合适的。本文提及的研究总体上产生了非常有趣的结果，当前的综述突出了在产品中提供关于阿斯巴甜存在的可见且详细信息这一社会问题。对涉及阿斯巴甜对肥胖、糖尿病、儿童和胎儿、自闭症、神经退行性变、苯丙酮尿症、过敏和皮肤问题的影响、其致癌特性及其遗传毒性的研究进行了分析。应进一步开展研究以确保关于阿斯巴甜对健康影响的信息清晰明确。
