Arrais Aldo, Bona Elisa, Todeschini Valeria, Caramaschi Alice, Massa Nadia, Roncoli Maddalena, Minervi Alessia, Perin Elena, Gianotti Valentina
Dipartimento per lo Sviluppo Sostenibile e la Transizione Ecologica, Università del Piemonte Orientale, 13100 Vercelli, Italy.
Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, 15121 Alessandria, Italy.
Pharmaceutics. 2023 Mar 11;15(3):914. doi: 10.3390/pharmaceutics15030914.
Antimicrobial resistance related to the misuse of antibiotics is a well-known current topic. Their excessive use in several fields has led to enormous selective pressure on pathogenic and commensal bacteria, driving the evolution of antimicrobial resistance genes with severe impacts on human health. Among all the possible strategies, a viable one could be the development of medical features that employ essential oils (EOs), complex natural mixtures extracted from different plant organs, rich in organic compounds showing, among others, antiseptic properties. In this work, green extracted essential oil of was included in cyclic oligosaccharides cyclodextrins (CD) and prepared in the form of tablets. This essential oil has been shown to have a strong transversal efficacy both as an antifungal and as an antibacterial agent. Its inclusion allows its effective use because an extension of the exposure time to the active compounds is obtained and, therefore, a more marked efficacy, especially against biofilm-producing microorganisms such as and , was registered. The efficacy of the tablet against candidiasis opens their possible use as a chewable tablet against oral candidiasis and as a vaginal tablet against vaginal candidiasis. Moreover, the registered wide efficacy is even more positive since the proposed approach can be defined as effective, safe, and green. In fact, the natural mixture of the essential oil is produced by the steam current method; therefore, the manufacturer employs substances that are not harmful, with very low production and management costs.
与抗生素滥用相关的抗菌药物耐药性是当前一个广为人知的话题。抗生素在多个领域的过度使用已对致病细菌和共生细菌产生了巨大的选择压力，推动了抗菌耐药基因的进化，对人类健康造成严重影响。在所有可能的策略中，一个可行的方法可能是开发利用精油（EOs）的医学特性，精油是从不同植物器官中提取的复杂天然混合物，富含多种具有防腐性能等的有机化合物。在这项工作中，将绿色提取的[具体植物名称]精油包封在环状寡糖环糊精（CD）中，并制成片剂形式。这种精油已被证明作为抗真菌和抗菌剂都具有很强的横向功效。将其包封可使其有效利用，因为这样能延长活性化合物的暴露时间，从而获得更显著的功效，尤其是对诸如[具体微生物名称1]和[具体微生物名称2]等产生生物膜的微生物的功效更为明显。该片剂对念珠菌病的疗效表明其有望用作治疗口腔念珠菌病的咀嚼片和治疗阴道念珠菌病的阴道片。此外，所记录的广泛疗效更加积极，因为所提出的方法可被定义为有效、安全且环保。事实上，精油的天然混合物是通过蒸汽法生产的；因此，制造商使用的物质无害，生产和管理成本极低。
