Afzal Ali, Jalalah Mohammed, Noor Abid, Khaliq Zubair, Qadir Muhammad Bilal, Masood Rashid, Nazir Ahsan, Ahmad Sheraz, Ahmad Faheem, Irfan Muhammad, Afzal Munazza, Faisal Mohd, Alsareii Saeed A, Harraz Farid A
Department of Textile Engineering, School of Engineering & Technology, National Textile University, Faisalabad 37610, Pakistan.
Promising Centre for Sensors and Electronic Devices (PCSED), Advanced Materials and Nano-Research Centre, Najran University, Najran 11001, Saudi Arabia.
Polymers (Basel). 2023 Mar 8;15(6):1355. doi: 10.3390/polym15061355.
Nowadays, synthetic polymers are used in medical applications due to their special biodegradable, biocompatible, hydrophilic, and non-toxic properties. The materials, which can be used for wound dressing fabrication with controlled drug release profile, are the need of the time. The main aim of this study was to develop and characterize polyvinyl alcohol/polycaprolactone (PVA/PCL) fibres containing a model drug. A dope solution comprising PVA/PCL with the drug was extruded into a coagulation bath and became solidified. The developed PVA/PCL fibres were then rinsed and dried. These fibres were tested for Fourier transform infrared spectroscopy, linear density, topographic analysis, tensile properties, liquid absorption, swelling behaviour, degradation, antimicrobial activity, and drug release profile for improved and better healing of the wound. From the results, it was concluded that PVA/PCL fibres containing a model drug can be produced by using the wet spinning technique and have respectable tensile properties; adequate liquid absorption, swelling %, and degradation %; and good antimicrobial activity with the controlled drug release profile of the model drug for wound dressing applications.
如今，合成聚合物因其特殊的生物可降解、生物相容、亲水性和无毒特性而被用于医学应用中。能够用于制造具有可控药物释放曲线的伤口敷料的材料是当下的需求。本研究的主要目的是开发并表征含有一种模型药物的聚乙烯醇/聚己内酯（PVA/PCL）纤维。将包含PVA/PCL与药物的纺丝溶液挤出到凝固浴中并固化。然后将所制备的PVA/PCL纤维冲洗并干燥。对这些纤维进行了傅里叶变换红外光谱、线密度、形貌分析、拉伸性能、液体吸收、溶胀行为、降解、抗菌活性以及药物释放曲线测试，以促进伤口更好地愈合。从结果得出，含有模型药物的PVA/PCL纤维可通过湿法纺丝技术制备，具有良好的拉伸性能；足够的液体吸收、溶胀百分比和降解百分比；并且具有良好的抗菌活性以及模型药物的可控药物释放曲线，可用于伤口敷料应用。
