Department of Pharmaceutical engineering, Dankook University, 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungcheongnam-do (Republic of, Korea.
Chem Asian J. 2022 Nov 2;17(21):e202200595. doi: 10.1002/asia.202200595. Epub 2022 Sep 19.
The development of ideal wound dressing with excellent properties, such as exudate absorption capacity, drug release control ability, and increased wound healing, is currently a major requirement for wound healing. Polyvinyl alcohol (PVA) is a biodegradable semi-crystalline synthetic polymer that has been used in the field of biotechnology such as tissue regeneration, wound dressing, and drug delivery systems. In recent years, PVA-based wound dressing materials have received considerable attention due to their excellent properties such as biodegradability, biocompatibility, non-toxicity and low cost. PVA can be used as a wound dressing material to create the necessary moist wound environment, improve the physical properties of the dressing, and increase the wound healing rates. In addition, PVA can also be mixed with other organic and inorganic materials and can be used for drug delivery and wound healing. This review article addresses the role of biomaterials based on PVA mixed with other ingredients for wound dressing. It also focuses on its recent use in wound dressings as carriers of active substances.
理想的伤口敷料应具备良好的性能，如渗出液吸收能力、药物释放控制能力和促进伤口愈合等，目前这是伤口愈合的主要需求。聚乙烯醇（PVA）是一种可生物降解的半结晶合成聚合物，已应用于组织再生、伤口敷料和药物输送系统等生物技术领域。近年来，基于 PVA 的伤口敷料材料因其生物降解性、生物相容性、无毒性和低成本等优良性能而受到广泛关注。PVA 可用作伤口敷料材料，以创造必要的湿润伤口环境、改善敷料的物理性能并提高伤口愈合率。此外，PVA 还可以与其他有机和无机材料混合使用，用于药物输送和伤口愈合。本文综述了 PVA 与其他成分混合的生物材料在伤口敷料中的作用，重点介绍了其作为活性物质载体在伤口敷料中的最新应用。
